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Cemip2 cell migration inducing hyaluronidase 2 [ Mus musculus (house mouse) ]

Gene ID: 83921, updated on 12-May-2024

Summary

Official Symbol
Cemip2provided by MGI
Official Full Name
cell migration inducing hyaluronidase 2provided by MGI
Primary source
MGI:MGI:1890373
See related
Ensembl:ENSMUSG00000024754 AllianceGenome:MGI:1890373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem2
Summary
Predicted to enable calcium ion binding activity and hyalurononglucosaminidase activity. Predicted to be involved in hyaluronan catabolic process. Predicted to act upstream of or within angiogenesis. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including heart; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 15.6), CNS E11.5 (RPKM 14.5) and 26 other tissues See more
Orthologs
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Genomic context

See Cemip2 in Genome Data Viewer
Location:
19 B; 19 15.54 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21755704..21835724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21778340..21858360)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:21788111-21788412 Neighboring gene abhydrolase domain containing 17B Neighboring gene STARR-positive B cell enhancer ABC_E9993 Neighboring gene STARR-positive B cell enhancer ABC_E9994 Neighboring gene VISTA enhancer mm1610 Neighboring gene STARR-seq mESC enhancer starr_45737 Neighboring gene STARR-seq mESC enhancer starr_45738 Neighboring gene predicted gene, 41818 Neighboring gene STARR-seq mESC enhancer starr_45740 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene lactate dehydrogenase B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45741 Neighboring gene STARR-seq mESC enhancer starr_45742 Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene predicted gene, 22506

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102198, mKIAA1412, 3110012M15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hyaluronan catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell surface hyaluronidase
Names
transmembrane protein 2
NP_001028931.1
NP_114386.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033759.2NP_001028931.1  cell surface hyaluronidase

    See identical proteins and their annotated locations for NP_001028931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034906, AK078530, BC089353, BU058152
    Consensus CDS
    CCDS37934.1
    UniProtKB/Swiss-Prot
    Q3UE15, Q3UE98, Q5FWI3, Q6DFZ0, Q6ZPR7, Q8VE53, Q9QY22
    Related
    ENSMUSP00000025663.7, ENSMUST00000025663.8
    Conserved Domains (3) summary
    cd13938
    Location:220387
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:123244
    G8; G8 domain
    pfam15711
    Location:12441333
    ILEI; Interleukin-like EMT inducer
  2. NM_031997.4NP_114386.3  cell surface hyaluronidase

    See identical proteins and their annotated locations for NP_114386.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034906, AK078530, AK149667, BC089353, BU058152
    Consensus CDS
    CCDS37934.1
    UniProtKB/Swiss-Prot
    Q3UE15, Q3UE98, Q5FWI3, Q6DFZ0, Q6ZPR7, Q8VE53, Q9QY22
    Related
    ENSMUSP00000093908.3, ENSMUST00000096194.9
    Conserved Domains (3) summary
    cd13938
    Location:220387
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:123244
    G8; G8 domain
    pfam15711
    Location:12441333
    ILEI; Interleukin-like EMT inducer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    21755704..21835724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)