U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

THO2 THO2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839081, updated on 7-Sep-2023

Summary

Go to the top of the page Help
Gene symbol
THO2
Gene description
THO2
Primary source
Araport:AT1G24706
Locus tag
AT1G24706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTHO2; EMB2793; EMBRYO DEFECTIVE 2793; F5A9.21; F5A9_21
Summary
Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
34
Sequence:
Chromosome: 1; NC_003070.9 (8741836..8755604)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. THO2, a core member of the THO/TREX complex, is required for microRNA production in Arabidopsis. Francisco-Mangilet AG, et al. Plant J, 2015 Jun. PMID 25976549
  2. Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene and endogenous siRNA biosynthesis. Yelina NE, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20634427, Free PMC Article
  3. A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Waidmann S, et al. Plant Cell, 2014 Nov. PMID 25387881, Free PMC Article
  4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. THO2, a core member of the THO/TREX complex, is required for microRNA production in Arabidopsis.
    Title: THO2, a core member of the THO/TREX complex, is required for microRNA production in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_001198157.1
NM_001332661.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within miRNA transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of THO complex IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
THO2
NP_001185086.1
  • THO2; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: THO complex, subunitTHOC2, C-region (InterPro:IPR021418), THO complex, subunitTHOC2, N-region (InterPro:IPR021726).
NP_173871.6
  • THO2; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: THO complex, subunitTHOC2, C-region (InterPro:IPR021418), THO complex, subunitTHOC2, N-region (InterPro:IPR021726); Has 19944 Blast hits to 14322 proteins in 730 species: Archae - 16; Bacteria - 829; Metazoa - 10835; Fungi - 2538; Plants - 1298; Viruses - 76; Other Eukaryotes - 4352 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    8741836..8755604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001332655.1 → NP_001321786.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W886, A0A1P8ARZ4, A0A384KN02, A0A7G2DWG2
    Conserved Domains (5) summary
    PRK12678
    Location:1333 → 1576
    PRK12678; transcription termination factor Rho; Provisional
    TIGR01622
    Location:1463 → 1580
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:912 → 1206
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:587 → 661
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:37 → 585
    THOC2_N; THO complex subunit 2 N-terminus

  2. NM_001332656.1 → NP_001321785.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7B6, A0A1P8ARY6, A0A384L8X5, A0A7G2DWG2
    Conserved Domains (5) summary
    PRK12678
    Location:1333 → 1576
    PRK12678; transcription termination factor Rho; Provisional
    TIGR01622
    Location:1463 → 1580
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:912 → 1206
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:587 → 661
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:37 → 585
    THOC2_N; THO complex subunit 2 N-terminus

  3. NM_001332657.1 → NP_001321784.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7B6, A0A1P8ARY6, A0A384L8X5, A0A7G2DWG2
    Conserved Domains (5) summary
    PRK12678
    Location:1333 → 1576
    PRK12678; transcription termination factor Rho; Provisional
    TIGR01622
    Location:1463 → 1580
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:912 → 1206
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:587 → 661
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:37 → 585
    THOC2_N; THO complex subunit 2 N-terminus

  4. NM_001332658.1 → NP_001321783.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7B6, A0A1P8ARY6, A0A384L8X5, A0A7G2DWG2
    Conserved Domains (5) summary
    PRK12678
    Location:1333 → 1576
    PRK12678; transcription termination factor Rho; Provisional
    TIGR01622
    Location:1463 → 1580
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:912 → 1206
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:587 → 661
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:37 → 585
    THOC2_N; THO complex subunit 2 N-terminus

  5. NM_001332659.1 → NP_001321782.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AS07, A0A7G2DWG2

  6. NM_001332660.1 → NP_001321781.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AS05, A0A7G2DWG2
    Conserved Domains (5) summary
    PRK12678
    Location:1244 → 1487
    PRK12678; transcription termination factor Rho; Provisional
    TIGR01622
    Location:1374 → 1491
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:823 → 1117
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:498 → 572
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:44 → 496
    THOC2_N; THO complex subunit 2 N-terminus

  7. NM_102309.6 → NP_173871.6  THO2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173871.6

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2DWG2, F4IAT3
    Conserved Domains (5) summary
    COG0642
    Location:511 → 671
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam11262
    Location:912 → 1206
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:587 → 661
    Thoc2; Transcription- and export-related complex subunit
    pfam12871
    Location:1474 → 1566
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16134
    Location:37 → 585
    THOC2_N; THO complex subunit 2 N-terminus

  8. NM_001198157.1 → NP_001185086.1  THO2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185086.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IAT2, Q8GUG8, Q9FXJ7, Q9FXJ8
    UniProtKB/TrEMBL
    A0A5S9VXT6, A0A654ENI3
    Conserved Domains (5) summary
    COG0642
    Location:511 → 671
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam11262
    Location:912 → 1206
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:587 → 661
    Thoc2; Transcription- and export-related complex subunit
    pfam12871
    Location:1474 → 1566
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam16134
    Location:37 → 585
    THOC2_N; THO complex subunit 2 N-terminus

  9. NM_001332661.1 → NP_001321780.1  THO2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARZ0, A0A7G2DWG2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4IAT2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools