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HASPIN histone H3 associated protein kinase [ Homo sapiens (human) ]

Gene ID: 83903, updated on 24-Nov-2020

Summary

Official Symbol
HASPINprovided by HGNC
Official Full Name
histone H3 associated protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:19682
See related
Ensembl:ENSG00000177602 MIM:609240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSG2
Orthologs

Genomic context

See HASPIN in Genome Data Viewer
Location:
17p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (3723903..3726699)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3627197..3629993)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene P2RX5-TAX1BP3 readthrough (NMD candidate) Neighboring gene ER membrane protein complex subunit 6 Neighboring gene purinergic receptor P2X 5 Neighboring gene integrin subunit alpha E Neighboring gene nonconserved acetylation island sequence 85 enhancer Neighboring gene nuclear cap binding subunit 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
histone kinase activity (H3-T3 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone kinase activity (H3-T3 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to chromosome, centromeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase haspin
Names
H-haspin
germ cell associated 2, haspin
germ cell-specific gene 2 protein
haploid germ cell-specific nuclear protein kinase
NP_114171.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031965.2NP_114171.2  serine/threonine-protein kinase haspin

    See identical proteins and their annotated locations for NP_114171.2

    Status: VALIDATED

    Source sequence(s)
    AF289865, BC016626, BC036181, BC047457
    Consensus CDS
    CCDS11036.1
    UniProtKB/Swiss-Prot
    Q8TF76
    UniProtKB/TrEMBL
    A0PJ70
    Related
    ENSP00000325290.4, ENST00000325418.5
    Conserved Domains (3) summary
    COG5072
    Location:322778
    ALK1; Serine/threonine kinase of the haspin family [Cell division and chromosome partitioning]
    pfam12330
    Location:710790
    DUF3635; Domain of unknown function (DUF3635)
    cl21453
    Location:488655
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    3723903..3726699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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