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KCTD10 potassium channel tetramerization domain containing 10 [ Homo sapiens (human) ]

Gene ID: 83892, updated on 29-Mar-2020

Summary

Official Symbol
KCTD10provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 10provided by HGNC
Primary source
HGNC:HGNC:23236
See related
Ensembl:ENSG00000110906 MIM:613421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTBD28; ULRO61; MSTP028; hBACURD3
Summary
The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in thyroid (RPKM 26.1), endometrium (RPKM 18.7) and 24 other tissues See more
Orthologs

Genomic context

See KCTD10 in Genome Data Viewer
Location:
12q24.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (109448655..109477300, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109886460..109915165, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1486 Neighboring gene myosin IH Neighboring gene ubiquitin protein ligase E3B Neighboring gene metabolism of cobalamin associated B Neighboring gene RNA, U4 small nuclear 32, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at 30 loci contribute to polygenic dyslipidemia.
NHGRI GWA Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
NHGRI GWA Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41739

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Names
BTB/POZ domain-containing protein KCTD10
potassium channel tetramerisation domain containing 10
potassium channel tetramerization domain-containing protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317395.2NP_001304324.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AY205299, BX333975, DA440672
    UniProtKB/Swiss-Prot
    Q9H3F6
    Conserved Domains (1) summary
    cd18399
    Location:26136
    BTB_POZ_KCTD10_BACURD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10)
  2. NM_001317399.2NP_001304328.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AY205299, AY597809
    UniProtKB/Swiss-Prot
    Q9H3F6
    Related
    ENSP00000441672.1, ENST00000540411.5
    Conserved Domains (2) summary
    smart00225
    Location:33131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:34124
    BTB_2; BTB/POZ domain
  3. NM_031954.5NP_114160.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2

    See identical proteins and their annotated locations for NP_114160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AY205299
    Consensus CDS
    CCDS9128.1
    UniProtKB/Swiss-Prot
    Q9H3F6
    UniProtKB/TrEMBL
    A0A024RBJ2
    Related
    ENSP00000228495.6, ENST00000228495.11
    Conserved Domains (1) summary
    pfam02214
    Location:34124
    BTB_2; BTB/POZ domain

RNA

  1. NR_133897.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007570, AK092170, AY205299
  2. NR_133898.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY205299, CX785497, DA440672

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    109448655..109477300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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