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SNX25 sorting nexin 25 [ Homo sapiens (human) ]

Gene ID: 83891, updated on 17-Jun-2019

Summary

Official Symbol
SNX25provided by HGNC
Official Full Name
sorting nexin 25provided by HGNC
Primary source
HGNC:HGNC:21883
See related
Ensembl:ENSG00000109762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBBI31; MSTP043
Expression
Broad expression in lung (RPKM 10.3), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs

Genomic context

See SNX25 in Genome Data Viewer
Location:
4q35.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (185204237..185368020)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186130773..186285120)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2436 Neighboring gene uncharacterized LOC105377588 Neighboring gene solute carrier family 25 member 4 Neighboring gene cilia and flagella associated protein 97 Neighboring gene uncharacterized LOC107986206 Neighboring gene LRP2 binding protein Neighboring gene ankyrin repeat domain 37 Neighboring gene UFM1 specific peptidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
type I transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317781.1NP_001304710.1  sorting nexin-25

    Status: VALIDATED

    Source sequence(s)
    AA626308, AC073344, AF113223, AY601647
    Consensus CDS
    CCDS34116.1
    UniProtKB/Swiss-Prot
    Q9H3E2
    Related
    ENSP00000426255.1, ENST00000504273.5
    Conserved Domains (4) summary
    cd06878
    Location:502624
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:291399
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:2160
    PXA; PXA domain
    pfam08628
    Location:701807
    Nexin_C; Sorting nexin C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    185204237..185368020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532308.3XP_011530610.1  sorting nexin-25 isoform X8

    Conserved Domains (4) summary
    cd08720
    Location:488596
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:843949
    Nexin_C; Sorting nexin C terminal
    cl02563
    Location:699801
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_011532302.3XP_011530604.1  sorting nexin-25 isoform X1

    Conserved Domains (4) summary
    cd06878
    Location:711833
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:500608
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:9101016
    Nexin_C; Sorting nexin C terminal
  3. XM_011532303.3XP_011530605.1  sorting nexin-25 isoform X2

    Conserved Domains (4) summary
    cd06878
    Location:710832
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:499607
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:9091015
    Nexin_C; Sorting nexin C terminal
  4. XM_011532304.3XP_011530606.1  sorting nexin-25 isoform X3

    Conserved Domains (4) summary
    cd06878
    Location:699821
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:488596
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:8981004
    Nexin_C; Sorting nexin C terminal
  5. XM_011532305.3XP_011530607.1  sorting nexin-25 isoform X4

    Conserved Domains (4) summary
    cd06878
    Location:678800
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:467575
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:877983
    Nexin_C; Sorting nexin C terminal
  6. XM_005263267.5XP_005263324.1  sorting nexin-25 isoform X6

    Related
    ENSP00000498676.1, ENST00000652585.1
    Conserved Domains (4) summary
    cd06878
    Location:666788
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:455563
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:865971
    Nexin_C; Sorting nexin C terminal
  7. XM_011532306.2XP_011530608.1  sorting nexin-25 isoform X5

    Conserved Domains (4) summary
    cd06878
    Location:711833
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:500608
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166324
    PXA; PXA domain
    pfam08628
    Location:910989
    Nexin_C; Sorting nexin C terminal
  8. XM_017008680.1XP_016864169.1  sorting nexin-25 isoform X7

  9. XM_017008687.1XP_016864176.1  sorting nexin-25 isoform X14

  10. XM_017008686.1XP_016864175.1  sorting nexin-25 isoform X13

  11. XM_017008684.2XP_016864173.1  sorting nexin-25 isoform X10

  12. XM_017008683.2XP_016864172.1  sorting nexin-25 isoform X9

  13. XM_024454240.1XP_024310008.1  sorting nexin-25 isoform X11

    Related
    ENSP00000483653.1, ENST00000618785.4
    Conserved Domains (3) summary
    cd06878
    Location:285407
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:74182
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam08628
    Location:484590
    Nexin_C; Sorting nexin C terminal
  14. XM_017008685.2XP_016864174.1  sorting nexin-25 isoform X12

RNA

  1. XR_938776.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031953.2: Suppressed sequence

    Description
    NM_031953.2: This RefSeq was removed because currently there is insufficient support for the transcript.
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