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SNX25 sorting nexin 25 [ Homo sapiens (human) ]

Gene ID: 83891, updated on 25-Nov-2021

Summary

Official Symbol
SNX25provided by HGNC
Official Full Name
sorting nexin 25provided by HGNC
Primary source
HGNC:HGNC:21883
See related
Ensembl:ENSG00000109762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBBI31; MSTP043
Expression
Broad expression in lung (RPKM 10.3), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
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Genomic context

See SNX25 in Genome Data Viewer
Location:
4q35.1
Exon count:
24
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (185204237..185363966)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186125391..186285120)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4736 Neighboring gene solute carrier family 25 member 4 Neighboring gene cilia and flagella associated protein 97 Neighboring gene Sharpr-MPRA regulatory region 12245 Neighboring gene LRP2BP antisense RNA 1 Neighboring gene LRP2 binding protein Neighboring gene ankyrin repeat domain 37 Neighboring gene UFM1 specific peptidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317781.2NP_001304710.1  sorting nexin-25 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AA626308, AC073344, AF113223, AY601647
    Consensus CDS
    CCDS34116.1
    UniProtKB/Swiss-Prot
    Q9H3E2
    Related
    ENSP00000426255.1, ENST00000504273.5
    Conserved Domains (4) summary
    cd06878
    Location:502624
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:291399
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:2160
    PXA; PXA domain
    pfam08628
    Location:701807
    Nexin_C; Sorting nexin C terminal
  2. NM_001378032.2NP_001364961.1  sorting nexin-25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (5) summary
    TIGR01612
    Location:331691
    235kDa-fam; reticulocyte binding/rhoptry protein
    cd06878
    Location:699821
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:488596
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166321
    PXA; PXA domain
    pfam08628
    Location:8981004
    Nexin_C; Sorting nexin C terminal
  3. NM_001378034.2NP_001364963.1  sorting nexin-25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Related
    ENSP00000498676.1, ENST00000652585.1
    Conserved Domains (4) summary
    cd06878
    Location:666788
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:455563
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166321
    PXA; PXA domain
    pfam08628
    Location:865971
    Nexin_C; Sorting nexin C terminal
  4. NM_001378035.2NP_001364964.1  sorting nexin-25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (4) summary
    cd08720
    Location:455563
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166321
    PXA; PXA domain
    pfam08628
    Location:810916
    Nexin_C; Sorting nexin C terminal
    cl02563
    Location:666768
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  5. NM_001378036.2NP_001364965.1  sorting nexin-25 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (4) summary
    cd06878
    Location:666788
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    cd08720
    Location:455563
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166321
    PXA; PXA domain
    pfam08628
    Location:865944
    Nexin_C; Sorting nexin C terminal
  6. NM_001378037.2NP_001364966.1  sorting nexin-25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (4) summary
    cd08720
    Location:455563
    RGS_SNX25; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein
    pfam02194
    Location:166321
    PXA; PXA domain
    pfam08628
    Location:810889
    Nexin_C; Sorting nexin C terminal
    cl02563
    Location:666768
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  7. NM_001378038.2NP_001364967.1  sorting nexin-25 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (1) summary
    pfam02194
    Location:166321
    PXA; PXA domain
  8. NM_001378039.2NP_001364968.1  sorting nexin-25 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (1) summary
    pfam02194
    Location:166321
    PXA; PXA domain
  9. NM_001378040.2NP_001364969.1  sorting nexin-25 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC073344
    Conserved Domains (1) summary
    pfam02194
    Location:166321
    PXA; PXA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    185204237..185363966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031953.2: Suppressed sequence

    Description
    NM_031953.2: This RefSeq was removed because currently there is insufficient support for the transcript.
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