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FGFBP2 fibroblast growth factor binding protein 2 [ Homo sapiens (human) ]

Gene ID: 83888, updated on 5-Mar-2024

Summary

Official Symbol
FGFBP2provided by HGNC
Official Full Name
fibroblast growth factor binding protein 2provided by HGNC
Primary source
HGNC:HGNC:29451
See related
Ensembl:ENSG00000137441 MIM:607713; AllianceGenome:HGNC:29451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KSP37; HBP17RP
Summary
This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]
Expression
Biased expression in bone marrow (RPKM 17.7), spleen (RPKM 6.7) and 7 other tissues See more
Orthologs
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Genomic context

See FGFBP2 in Genome Data Viewer
Location:
4p15.32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (15960245..15963175, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (15941926..15944856, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15961868..15964798, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hypoxanthine phosphoribosyltransferase 1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15911215-15911375 Neighboring gene fibroblast growth factor binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:15964828-15965669 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:15982103-15982696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:15982697-15983289 Neighboring gene prominin 1 Neighboring gene U6 spliceosomal RNA Neighboring gene Sharpr-MPRA regulatory region 9620 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:16069501-16070094 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:16078051-16078768 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:16078769-16079486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21346 Neighboring gene uncharacterized LOC107986261

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of fibroblast growth factor binding protein 2 (FGFBP2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibroblast growth factor-binding protein 2
Names
37 kDa killer-specific secretory protein
FGF-BP2
FGF-binding protein 2
FGFBP-2
HBp17-RP
HBp17-related protein
killer-specific secretory protein of 37 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031950.4NP_114156.1  fibroblast growth factor-binding protein 2 precursor

    See identical proteins and their annotated locations for NP_114156.1

    Status: REVIEWED

    Source sequence(s)
    AC005598, AY358978, CN480296
    Consensus CDS
    CCDS3419.1
    UniProtKB/Swiss-Prot
    Q9BYJ0
    Related
    ENSP00000259989.6, ENST00000259989.7
    Conserved Domains (1) summary
    pfam06473
    Location:9223
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    15960245..15963175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    15941926..15944856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)