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PRSS27 serine protease 27 [ Homo sapiens (human) ]

Gene ID: 83886, updated on 25-Jan-2022

Summary

Official Symbol
PRSS27provided by HGNC
Official Full Name
serine protease 27provided by HGNC
Primary source
HGNC:HGNC:15475
See related
Ensembl:ENSG00000172382 MIM:608018; AllianceGenome:HGNC:15475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPN; CAPH2
Summary
This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in esophagus (RPKM 55.3) and skin (RPKM 0.9) See more
Orthologs
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Genomic context

See PRSS27 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2712418..2720224, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2762423..2770225, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group K13 member 1 Neighboring gene potassium channel tetramerization domain containing 5 Neighboring gene SRRM2 antisense RNA 1 Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene elongin B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44546

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease 27
Names
channel-activating protease 2
marapsin
pancreasin
protease, serine 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318395.2NP_001305324.1  serine protease 27 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which lacks a portion of the N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AY359106, BC036912
    UniProtKB/Swiss-Prot
    Q9BQR3
    Conserved Domains (2) summary
    smart00020
    Location:4170
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:4173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_031948.5NP_114154.1  serine protease 27 isoform 1 precursor

    See identical proteins and their annotated locations for NP_114154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC034294, BC036912
    Consensus CDS
    CCDS10476.1
    UniProtKB/Swiss-Prot
    Q9BQR3
    Related
    ENSP00000306390.3, ENST00000302641.8
    Conserved Domains (2) summary
    smart00020
    Location:34272
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:36275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2712418..2720224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522689.2XP_011520991.1  serine protease 27 isoform X1

    See identical proteins and their annotated locations for XP_011520991.1

    Conserved Domains (2) summary
    smart00020
    Location:4170
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:4173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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