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MIXL1 Mix paired-like homeobox [ Homo sapiens (human) ]

Gene ID: 83881, updated on 11-Sep-2019

Summary

Official Symbol
MIXL1provided by HGNC
Official Full Name
Mix paired-like homeoboxprovided by HGNC
Primary source
HGNC:HGNC:13363
See related
Ensembl:ENSG00000185155 MIM:609852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIX; MIXL; MILD1
Summary
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in lymph node (RPKM 1.1), urinary bladder (RPKM 0.8) and 11 other tissues See more
Orthologs

Genomic context

See MIXL1 in Genome Data Viewer
Location:
1q42.12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (226223664..226227060)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226411325..226414756)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ACBD3 antisense RNA 1 Neighboring gene acyl-CoA binding domain containing 3 Neighboring gene uncharacterized LOC101927247 Neighboring gene ribosomal protein L34 pseudogene 7 Neighboring gene lin-9 DREAM MuvB core complex component Neighboring gene Y-box binding protein 1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Mix paired-like homeobox (MIXL1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of Mix paired-like homeobox (MIXL1) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
    Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...

General gene information

Markers

Homology

Clone Names

  • MGC138179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
 
digestive tract development ISS
Inferred from Sequence or Structural Similarity
more info
 
endoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
endodermal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of hematopoietic progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesoderm development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homeobox protein MIXL1
Names
MIX1 homeobox-like protein 1
Mix-like homeobox protein 1
homeodomain protein MIX
mix.1 homeobox-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282402.2NP_001269331.1  homeobox protein MIXL1 isoform 1

    See identical proteins and their annotated locations for NP_001269331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL592045, BC143784, CX165667
    Consensus CDS
    CCDS60432.1
    UniProtKB/Swiss-Prot
    Q9H2W2
    Related
    ENSP00000442439.1, ENST00000542034.5
    Conserved Domains (1) summary
    pfam00046
    Location:89150
    Homeobox; Homeobox domain
  2. NM_031944.3NP_114150.1  homeobox protein MIXL1 isoform 2

    See identical proteins and their annotated locations for NP_114150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL592045, BC111974, CX165667
    Consensus CDS
    CCDS1552.1
    UniProtKB/Swiss-Prot
    Q9H2W2
    UniProtKB/TrEMBL
    A0A024R3T7
    Related
    ENSP00000355775.4, ENST00000366810.5
    Conserved Domains (1) summary
    pfam00046
    Location:89142
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    226223664..226227060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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