Format

Send to:

Choose Destination

CDCA7 cell division cycle associated 7 [ Homo sapiens (human) ]

Gene ID: 83879, updated on 11-Jun-2021

Summary

Official Symbol
CDCA7provided by HGNC
Official Full Name
cell division cycle associated 7provided by HGNC
Primary source
HGNC:HGNC:14628
See related
Ensembl:ENSG00000144354 MIM:609937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICF3; JPO1
Summary
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 15.2), duodenum (RPKM 15.1) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CDCA7 in Genome Data Viewer
Location:
2q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (173354861..173368997)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (174219600..174233725)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 18 Neighboring gene cytochrome c oxidase subunit 7B pseudogene Neighboring gene uncharacterized LOC105373744 Neighboring gene JPT1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.
GeneReviews: Not available
Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.
GeneReviews: Not available
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
GeneReviews: Not available
Immunodeficiency-centromeric instability-facial anomalies syndrome 3
MedGen: C4310799 OMIM: 616910 GeneReviews: Not available
Compare labs
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14722, FLJ14736, MGC34109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division cycle-associated protein 7
Names
c-Myc target JPO1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047202.1 RefSeqGene

    Range
    5856..19981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_031942.5NP_114148.3  cell division cycle-associated protein 7 isoform 1

    See identical proteins and their annotated locations for NP_114148.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092573, AY029179, BC015124, DA531905
    Consensus CDS
    CCDS2252.1
    UniProtKB/Swiss-Prot
    Q9BWT1
    Related
    ENSP00000306968.3, ENST00000306721.8
    Conserved Domains (1) summary
    pfam10497
    Location:341439
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
  2. NM_145810.3NP_665809.1  cell division cycle-associated protein 7 isoform 2

    See identical proteins and their annotated locations for NP_665809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AC092573, AY029179, BC015124
    Consensus CDS
    CCDS2253.1
    UniProtKB/Swiss-Prot
    Q9BWT1
    Related
    ENSP00000272789.4, ENST00000347703.7
    Conserved Domains (1) summary
    pfam10497
    Location:266360
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    173354861..173368997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_923034.1 RNA Sequence

    Related
    ENST00000467411.5
Support Center