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MRO maestro [ Homo sapiens (human) ]

Gene ID: 83876, updated on 25-Nov-2025
Official Symbol
MROprovided by HGNC
Official Full Name
maestroprovided by HGNC
Primary source
HGNC:HGNC:24121
See related
Ensembl:ENSG00000134042 MIM:608080; AllianceGenome:HGNC:24121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B29; C18orf3
Summary
This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 16.9), kidney (RPKM 11.1) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See MRO in Genome Data Viewer
Location:
18q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (50795130..50825380, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (50996813..51027082, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (48321500..48351750, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 4 Neighboring gene uncharacterized LOC124904302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:48247846-48248346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:48248347-48248847 Neighboring gene uncharacterized LOC105372116 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:48302541-48303248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:48346071-48346704 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13322 Neighboring gene ribosomal protein L17 pseudogene 46 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:48405277-48405778 Neighboring gene MPRA-validated peak3150 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9459 Neighboring gene malic enzyme 2 Neighboring gene MPRA-validated peak3151 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9460 Neighboring gene uncharacterized LOC107985152 Neighboring gene elaC ribonuclease Z 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The elusive MAESTRO gene: Its human reproductive tissue-specific expression pattern. Kenigsberg S, et al. PLoS One, 2017. PMID 28406912, Free PMC Article
  2. Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein. Smith L, et al. Dev Dyn, 2003 Aug. PMID 12889070
  3. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. Yanaihara N, et al. Genomics, 2001 Mar 1. PMID 11401430
  4. Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific. Zouboulis CC, et al. J Eur Acad Dermatol Venereol, 2020 Jul. PMID 32031713
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ30140

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein maestro
Names
beside the Ma29 deletion
male-specific transcription in the developing reproductive organs

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127174.3 → NP_001120646.1  protein maestro isoform b

    See identical proteins and their annotated locations for NP_001120646.1

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS45869.1
    UniProtKB/TrEMBL
    K7EPK7
    Related
    ENSP00000465653.1, ENST00000588444.5

  2. NM_001127175.3 → NP_001120647.1  protein maestro isoform c

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS45867.1
    UniProtKB/Swiss-Prot
    Q9BYG7
    Related
    ENSP00000392614.1, ENST00000431965.6

  3. NM_001127176.3 → NP_001120648.1  protein maestro isoform d

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS45868.1
    UniProtKB/Swiss-Prot
    Q9BYG7
    Related
    ENSP00000397900.1, ENST00000436348.6

  4. NM_001369508.2 → NP_001356437.1  protein maestro isoform a

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS11947.1
    UniProtKB/Swiss-Prot
    B7Z2I5, B7Z3B2, E9PAT5, E9PBI3, K7EKJ8, Q8N6K5, Q9BYG7
    Related
    ENSP00000256425.2, ENST00000256425.6

  5. NM_001369510.2 → NP_001356439.1  protein maestro isoform a

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS11947.1
    UniProtKB/Swiss-Prot
    B7Z2I5, B7Z3B2, E9PAT5, E9PBI3, K7EKJ8, Q8N6K5, Q9BYG7
    Related
    ENSP00000555837.1, ENST00000885778.1

  6. NM_001369511.2 → NP_001356440.1  protein maestro isoform b

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS45869.1
    UniProtKB/TrEMBL
    K7EPK7

  7. NM_001369515.2 → NP_001356444.1  protein maestro isoform b

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS45869.1
    UniProtKB/TrEMBL
    K7EPK7
    Related
    ENSP00000555838.1, ENST00000885779.1

  8. NM_031939.6 → NP_114145.2  protein maestro isoform a

    See identical proteins and their annotated locations for NP_114145.2

    Status: REVIEWED

    Source sequence(s)
    AC015864
    Consensus CDS
    CCDS11947.1
    UniProtKB/Swiss-Prot
    B7Z2I5, B7Z3B2, E9PAT5, E9PBI3, K7EKJ8, Q8N6K5, Q9BYG7
    Related
    ENSP00000381465.2, ENST00000398439.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    50795130..50825380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437883.1 → XP_047293839.1  protein maestro isoform X3

  2. XM_011526226.4 → XP_011524528.1  protein maestro isoform X2

    See identical proteins and their annotated locations for XP_011524528.1

    UniProtKB/TrEMBL
    K7EPK7
    Related
    ENSP00000467427.1, ENST00000592966.5

  3. XM_047437882.1 → XP_047293838.1  protein maestro isoform X1

    UniProtKB/Swiss-Prot
    B7Z2I5, B7Z3B2, E9PAT5, E9PBI3, K7EKJ8, Q8N6K5, Q9BYG7
    Related
    ENSP00000555843.1, ENST00000885784.1

  4. XM_017026035.3 → XP_016881524.1  protein maestro isoform X1

    UniProtKB/Swiss-Prot
    B7Z2I5, B7Z3B2, E9PAT5, E9PBI3, K7EKJ8, Q8N6K5, Q9BYG7
    Related
    ENSP00000555839.1, ENST00000885780.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    50996813..51027082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319259.1 → XP_054175234.1  protein maestro isoform X3

  2. XM_054319258.1 → XP_054175233.1  protein maestro isoform X2

    UniProtKB/TrEMBL
    K7EPK7

  3. XM_054319257.1 → XP_054175232.1  protein maestro isoform X1

  4. XM_054319256.1 → XP_054175231.1  protein maestro isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYG7.2 GenPept UniProtKB/Swiss-Prot:Q9BYG7

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