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TBC1D10A TBC1 domain family member 10A [ Homo sapiens (human) ]

Gene ID: 83874, updated on 4-Dec-2022

Summary

Official Symbol
TBC1D10Aprovided by HGNC
Official Full Name
TBC1 domain family member 10Aprovided by HGNC
Primary source
HGNC:HGNC:23609
See related
Ensembl:ENSG00000099992 MIM:610020; AllianceGenome:HGNC:23609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPI64; TBC1D10; dJ130H16.1; dJ130H16.2
Summary
Enables PDZ domain binding activity. Involved in activation of cysteine-type endopeptidase activity and retrograde transport, endosome to Golgi. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 13.6), placenta (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

See TBC1D10A in Genome Data Viewer
Location:
22q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30291990..30326941, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30755329..30790284, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30687979..30722930, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene oncostatin M Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene origin of replication in TBC1D10A Neighboring gene splicing factor 3a subunit 1 Neighboring gene coiled-coil domain containing 157 Neighboring gene KIAA1656 protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TBC1 domain family, member 10A (TBC1D10A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in microvillus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TBC1 domain family member 10A
Names
EBP50-PDX interactor of 64 kDa
EBP50-PDZ interactor of 64 kD
rab27A-GAP-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204240.2NP_001191169.1  TBC1 domain family member 10A isoform 1

    See identical proteins and their annotated locations for NP_001191169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK127939, BC150187, DA944522
    Consensus CDS
    CCDS56227.1
    UniProtKB/Swiss-Prot
    Q9BXI6
    UniProtKB/TrEMBL
    A7E244
    Related
    ENSP00000384996.3, ENST00000403477.7
    Conserved Domains (2) summary
    smart00164
    Location:117320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl27169
    Location:403502
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
  2. NM_031937.3NP_114143.1  TBC1 domain family member 10A isoform 2

    See identical proteins and their annotated locations for NP_114143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) used an alternate in-frame splice site in the 5_ coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC150187, BC171775, DA944522
    Consensus CDS
    CCDS13874.1
    UniProtKB/Swiss-Prot
    Q543A2, Q9BXI6
    UniProtKB/TrEMBL
    A7E244, B7ZVY9
    Related
    ENSP00000215790.8, ENST00000215790.12
    Conserved Domains (2) summary
    smart00164
    Location:110313
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PRK03427
    Location:396495
    PRK03427; cell division protein ZipA; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    30291990..30326941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    30755329..30790284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)