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FSD1L fibronectin type III and SPRY domain containing 1 like [ Homo sapiens (human) ]

Gene ID: 83856, updated on 5-Aug-2018

Summary

Official Symbol
FSD1Lprovided by HGNC
Official Full Name
fibronectin type III and SPRY domain containing 1 likeprovided by HGNC
Primary source
HGNC:HGNC:13753
See related
Ensembl:ENSG00000106701 MIM:609829; Vega:OTTHUMG00000020426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR1; CCDC10; FSD1CL; FSD1NL; CSDUFD1
Expression
Broad expression in brain (RPKM 4.1), testis (RPKM 1.7) and 22 other tissues See more
Orthologs

Genomic context

See FSD1L in Genome Data Viewer
Location:
9q31.2
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (105442183..105552433)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (108210077..108314714)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376197 Neighboring gene RNA, 7SK small nuclear pseudogene 191 Neighboring gene uncharacterized LOC112268038 Neighboring gene solute carrier family 44 member 1 Neighboring gene Ral GTPase activating protein catalytic alpha subunit 1 pseudogene 1 Neighboring gene uncharacterized LOC105376199 Neighboring gene fukutin Neighboring gene GATA motif-containing MPRA enhancer 228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FSD1-like protein
Names
FSD1 C-terminal like
FSD1 N-terminal like
coiled-coil domain containing 10
cystatin and DUF19 domain containing 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145313.2NP_001138785.1  FSD1-like protein isoform 3

    See identical proteins and their annotated locations for NP_001138785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AK299350, AK309817, BC036746, CR936789
    Consensus CDS
    CCDS47999.1
    UniProtKB/Swiss-Prot
    Q9BXM9
    UniProtKB/TrEMBL
    Q8N450
    Related
    ENSP00000417492.1, OTTHUMP00000212557, ENST00000481272.5, OTTHUMT00000349935
    Conserved Domains (3) summary
    cd00063
    Location:197297
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:302505
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:36162
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. NM_001287191.1NP_001274120.1  FSD1-like protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and contains an additional in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (4) is shorter than isoform 3.
    Source sequence(s)
    AK296433, AK299491, BC036746, BP229804, CR936789
    Consensus CDS
    CCDS75870.1
    UniProtKB/Swiss-Prot
    Q9BXM9
    UniProtKB/TrEMBL
    A0A0A0MRS5, B7Z3W5, Q8N450
    Related
    ENSP00000363842.4, ENST00000374710.7
    Conserved Domains (3) summary
    cd00063
    Location:165265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270483
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:4130
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. NM_001287192.1NP_001274121.1  FSD1-like protein isoform 5

    See identical proteins and their annotated locations for NP_001274121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (5) is shorter than isoform 3.
    Source sequence(s)
    AK299491, BC036746, BP229804, BP365251, CR936789
    Consensus CDS
    CCDS6765.3
    UniProtKB/Swiss-Prot
    Q9BXM9
    UniProtKB/TrEMBL
    A0A0C4DG97, Q8N450
    Related
    ENSP00000419691.1, OTTHUMP00000212556, ENST00000484973.5, OTTHUMT00000349934
    Conserved Domains (3) summary
    cd00063
    Location:165265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270472
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:4130
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. NM_001330739.1NP_001317668.1  FSD1-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL158070, AL161627, BP229804, CR936789, DC343340
    Consensus CDS
    CCDS83391.1
    UniProtKB/TrEMBL
    F8W946
    Related
    ENSP00000378384.3, ENST00000394926.7
    Conserved Domains (3) summary
    cd00063
    Location:165265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270484
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:4130
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  5. NM_031919.4NP_114125.1  FSD1-like protein isoform 2

    See identical proteins and their annotated locations for NP_114125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and also lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 3. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 3.
    Source sequence(s)
    AF316830, BP229804
    Consensus CDS
    CCDS6764.1
    UniProtKB/Swiss-Prot
    Q9BXM9
    Related
    ENSP00000487223.1, OTTHUMP00000278457, ENST00000469022.5, OTTHUMT00000053513
    Conserved Domains (1) summary
    cl25407
    Location:4113
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    105442183..105552433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015185.1XP_016870674.1  FSD1-like protein isoform X9

    Related
    ENSP00000420624.1, OTTHUMP00000212559, ENST00000495708.5, OTTHUMT00000349937
  2. XM_011519079.2XP_011517381.2  FSD1-like protein isoform X3

  3. XM_011519078.2XP_011517380.2  FSD1-like protein isoform X2

  4. XM_011519077.2XP_011517379.1  FSD1-like protein isoform X1

    Conserved Domains (3) summary
    cd00063
    Location:203303
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:308522
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:42168
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  5. XM_005252254.2XP_005252311.1  FSD1-like protein isoform X4

    Conserved Domains (3) summary
    cd00063
    Location:197297
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:302516
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:36162
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  6. XM_017015182.1XP_016870671.1  FSD1-like protein isoform X5

  7. XM_017015183.1XP_016870672.1  FSD1-like protein isoform X6

    UniProtKB/Swiss-Prot
    Q9BXM9
  8. XM_017015187.1XP_016870676.1  FSD1-like protein isoform X11

  9. XM_005252260.3XP_005252317.1  FSD1-like protein isoform X7

    Conserved Domains (2) summary
    cd00063
    Location:52140
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:145359
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
  10. XM_024447690.1XP_024303458.1  FSD1-like protein isoform X8

    Conserved Domains (2) summary
    cd00063
    Location:52140
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:145348
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
  11. XM_017015184.1XP_016870673.1  FSD1-like protein isoform X7

    Conserved Domains (2) summary
    cd00063
    Location:52140
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:145359
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
  12. XM_011519080.2XP_011517382.1  FSD1-like protein isoform X10

    Conserved Domains (2) summary
    cd00063
    Location:278
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:83297
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
  13. XM_011519081.2XP_011517383.1  FSD1-like protein isoform X12

    See identical proteins and their annotated locations for XP_011517383.1

    UniProtKB/TrEMBL
    Q8N450
    Related
    ENSP00000363839.1, OTTHUMP00000021845, ENST00000374707.1, OTTHUMT00000053511
    Conserved Domains (2) summary
    cd00063
    Location:278
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:83286
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207647.2: Suppressed sequence

    Description
    NM_207647.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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