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SYT16 synaptotagmin 16 [ Homo sapiens (human) ]

Gene ID: 83851, updated on 23-Sep-2020

Summary

Official Symbol
SYT16provided by HGNC
Official Full Name
synaptotagmin 16provided by HGNC
Primary source
HGNC:HGNC:23142
See related
Ensembl:ENSG00000139973 MIM:610950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYT14L; syt14r; Strep14; CHR14SYT
Expression
Biased expression in brain (RPKM 5.2), prostate (RPKM 0.7) and 2 other tissues See more
Orthologs

Genomic context

See SYT16 in Genome Data Viewer
Location:
14q23.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (61812162..62112825)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (62331567..62573915)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HIF1A antisense RNA 3 Neighboring gene hypoxia inducible factor 1 subunit alpha Neighboring gene HIF1A antisense RNA 2 Neighboring gene small nuclear RNA activating complex polypeptide 1 Neighboring gene cytochrome c oxidase subunit 4I1 pseudogene 1 Neighboring gene molybdenum cofactor synthesis 3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 643 Neighboring gene tubulin alpha 1c pseudogene Neighboring gene long intergenic non-protein coding RNA 644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of self-rated health.
GeneReviews: Not available
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
GeneReviews: Not available
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptotagmin-16
Names
chr14 synaptotagmin
synaptotagmin 14-like protein
synaptotagmin XIV-related protein
synaptotagmin XVI

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367650.1NP_001354579.1  synaptotagmin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  2. NM_001367652.1NP_001354581.1  synaptotagmin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  3. NM_001367654.1NP_001354583.1  synaptotagmin-16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  4. NM_001367656.1NP_001354585.1  synaptotagmin-16 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
    Consensus CDS
    CCDS45121.1
    Related
    ENSP00000478637.1, ENST00000568344.5
  5. NM_001367657.1NP_001354586.1  synaptotagmin-16 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  6. NM_001367659.1NP_001354588.1  synaptotagmin-16 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  7. NM_001367661.1NP_001354590.1  synaptotagmin-16 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  8. NM_001367663.1NP_001354592.1  synaptotagmin-16 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816
  9. NM_001387087.1NP_001374016.1  synaptotagmin-16 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 4, 7, and 9, encodes isoform 4.
    Source sequence(s)
    AL137918, AL356018, AL390816
  10. NM_001387088.1NP_001374017.1  synaptotagmin-16 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL137918, AL356018, AL390816

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    61812162..62112825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449723.1XP_024305491.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:506643
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  2. XM_024449724.1XP_024305492.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:506643
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  3. XM_024449727.1XP_024305495.1  synaptotagmin-16 isoform X4

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cl14603
    Location:506541
    C2; C2 domain
  4. XM_024449725.1XP_024305493.1  synaptotagmin-16 isoform X2

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cl14603
    Location:506568
    C2; C2 domain
  5. XM_024449726.1XP_024305494.1  synaptotagmin-16 isoform X3

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cl14603
    Location:506541
    C2; C2 domain
  6. XM_017021697.2XP_016877186.1  synaptotagmin-16 isoform X10

  7. XM_024449721.1XP_024305489.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:506643
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  8. XM_006720272.3XP_006720335.1  synaptotagmin-16 isoform X1

    See identical proteins and their annotated locations for XP_006720335.1

    UniProtKB/Swiss-Prot
    Q17RD7
    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:506643
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  9. XM_024449728.1XP_024305496.1  synaptotagmin-16 isoform X12

    Conserved Domains (2) summary
    cd08389
    Location:44167
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:200337
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  10. XM_024449720.1XP_024305488.1  synaptotagmin-16 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:350473
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:506643
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  11. XM_024449730.1XP_024305498.1  synaptotagmin-16 isoform X12

    Conserved Domains (2) summary
    cd08389
    Location:44167
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:200337
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  12. XM_024449729.1XP_024305497.1  synaptotagmin-16 isoform X12

    Conserved Domains (2) summary
    cd08389
    Location:44167
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:200337
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
  13. XM_011537227.2XP_011535529.2  synaptotagmin-16 isoform X7

  14. XM_011537229.2XP_011535531.1  synaptotagmin-16 isoform X11

    Conserved Domains (2) summary
    cd08389
    Location:129252
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:285422
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

RNA

  1. XR_002957566.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031914.2: Suppressed sequence

    Description
    NM_031914.2: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
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