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SYT15 synaptotagmin 15 [ Homo sapiens (human) ]

Gene ID: 83849, updated on 23-Nov-2021

Summary

Official Symbol
SYT15provided by HGNC
Official Full Name
synaptotagmin 15provided by HGNC
Primary source
HGNC:HGNC:17167
See related
Ensembl:ENSG00000204176 MIM:608081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
sytXV; CHR10SYT
Summary
This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 8.5), lymph node (RPKM 2.1) and 18 other tissues See more
Orthologs
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Genomic context

See SYT15 in Genome Data Viewer
Location:
10q11.22
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (46578018..46595170)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (46955444..46970489, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y4 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene uncharacterized LOC101927699 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 1 Neighboring gene uncharacterized LOC105378289 Neighboring gene shieldin complex subunit 2 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 2637

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptotagmin-15
Names
chr10 synaptotagmin
synaptotagmin XV
synaptotagmin XV-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031912.5NP_114118.2  synaptotagmin-15 isoform a

    See identical proteins and their annotated locations for NP_114118.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (a).
    Source sequence(s)
    AA878734, AB109022, AJ303363, AL356056, DB158555
    Consensus CDS
    CCDS73103.1
    UniProtKB/Swiss-Prot
    Q9BQS2
    Related
    ENSP00000363441.4, ENST00000374321.9
    Conserved Domains (2) summary
    cd08390
    Location:149269
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:279416
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15
  2. NM_181519.3NP_852660.1  synaptotagmin-15 isoform b

    See identical proteins and their annotated locations for NP_852660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) contains an alternate 3' sequence, compared to variant a. The resulting isoform (b) contains a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL356056
    Consensus CDS
    CCDS73104.1
    UniProtKB/Swiss-Prot
    Q9BQS2
    Conserved Domains (2) summary
    cd08390
    Location:149269
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:279378
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    46578018..46595170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448228.1XP_024303996.1  synaptotagmin-15 isoform X1

    Related
    ENSP00000363443.3, ENST00000374323.8
    Conserved Domains (2) summary
    cd08390
    Location:202322
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:332469
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15
  2. XM_017016753.2XP_016872242.1  synaptotagmin-15 isoform X4

  3. XM_017016752.1XP_016872241.1  synaptotagmin-15 isoform X3

    UniProtKB/Swiss-Prot
    Q9BQS2
    Conserved Domains (2) summary
    cd08390
    Location:149269
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:279378
    C2; C2 domain
  4. XM_006718011.2XP_006718074.1  synaptotagmin-15 isoform X3

    See identical proteins and their annotated locations for XP_006718074.1

    UniProtKB/Swiss-Prot
    Q9BQS2
    Related
    ENSP00000427607.1, ENST00000503753.5
    Conserved Domains (2) summary
    cd08390
    Location:149269
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:279378
    C2; C2 domain
  5. XM_017016751.2XP_016872240.1  synaptotagmin-15 isoform X3

    UniProtKB/Swiss-Prot
    Q9BQS2
    Conserved Domains (2) summary
    cd08390
    Location:149269
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:279378
    C2; C2 domain
  6. XM_017016750.2XP_016872239.1  synaptotagmin-15 isoform X2

    Conserved Domains (2) summary
    cd08390
    Location:156276
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:286423
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

RNA

  1. XR_428721.3 RNA Sequence

  2. XR_001747224.2 RNA Sequence

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