Format

Send to:

Choose Destination

Crot carnitine O-octanoyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 83842, updated on 12-Jan-2022

Summary

Official Symbol
Crotprovided by RGD
Official Full Name
carnitine O-octanoyltransferaseprovided by RGD
Primary source
RGD:70908
See related
Ensembl:ENSRNOG00000006779
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables carnitine O-octanoyltransferase activity. Involved in response to organonitrogen compound and response to xenobiotic stimulus. Located in peroxisome. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 573.1), Kidney (RPKM 269.5) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Crot in Genome Data Viewer
Location:
4q12
Exon count:
27
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25068270..25133111)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22079837..22116265)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102219 Neighboring gene eukaryotic translation initiation factor 3 subunit K-like Neighboring gene uncharacterized LOC120102221 Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene uncharacterized LOC120102222 Neighboring gene ATP-binding cassette, subfamily B (MDR/TAP), member 1B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-octanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carnitine O-octanoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carnitine O-octanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-octanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables carnitine O-octanoyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in carnitine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in coenzyme A metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in coenzyme A metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
 
involved_in generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of precursor metabolites and energy ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in long-chain fatty acid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in medium-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in medium-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in medium-chain fatty acid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal carnitine O-octanoyltransferase
Names
COT
NP_114193.2
XP_006236066.1
XP_006236067.1
XP_038964380.1
XP_038964381.1
XP_038964382.1
XP_038964383.1
XP_038964384.1
XP_038964385.1
XP_038964386.1
XP_038964387.1
XP_038964388.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031987.2NP_114193.2  peroxisomal carnitine O-octanoyltransferase

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000141
    Related
    ENSRNOP00000063856.1, ENSRNOT00000067462.3
    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    25068270..25133111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108456.1XP_038964384.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:107690
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  2. XM_039108454.1XP_038964382.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Related
    ENSRNOP00000073847.2, ENSRNOT00000091799.2
    Conserved Domains (1) summary
    pfam00755
    Location:107690
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  3. XM_039108453.1XP_038964381.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:107690
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  4. XM_039108458.1XP_038964386.1  peroxisomal carnitine O-octanoyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  5. XM_039108452.1XP_038964380.1  peroxisomal carnitine O-octanoyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00755
    Location:160743
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  6. XM_039108457.1XP_038964385.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:107690
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  7. XM_039108455.1XP_038964383.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:107690
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  8. XM_039108460.1XP_038964388.1  peroxisomal carnitine O-octanoyltransferase isoform X4

    Related
    ENSRNOP00000071087.2, ENSRNOT00000090968.2
    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  9. XM_006236005.4XP_006236067.1  peroxisomal carnitine O-octanoyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006236067.1

    UniProtKB/TrEMBL
    Q6GMN6
    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  10. XM_006236004.4XP_006236066.1  peroxisomal carnitine O-octanoyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00755
    Location:73656
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  11. XM_039108459.1XP_038964387.1  peroxisomal carnitine O-octanoyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Support Center