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Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like [ Mus musculus (house mouse) ]

Gene ID: 83814, updated on 1-Sep-2018

Summary

Official Symbol
Nedd4lprovided by MGI
Official Full Name
neural precursor cell expressed, developmentally down-regulated gene 4-likeprovided by MGI
Primary source
MGI:MGI:1933754
See related
Ensembl:ENSMUSG00000024589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nedd4b; Nedd4-2; 1300012C07Rik
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E18 (RPKM 4.7) and 26 other tissues See more
Orthologs

Genomic context

See Nedd4l in Genome Data Viewer
Location:
18; 18 E1
Exon count:
39
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (64887683..65217826)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (65047410..65377480)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29860 Neighboring gene predicted gene, 46639 Neighboring gene predicted gene, 41756 Neighboring gene predicted gene, 41755 Neighboring gene predicted gene, 29966 Neighboring gene microRNA 122

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Gene trapped (1) 
  • Targeted (6)  1 citation

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of bicellular tight junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
response to metal ion ISO
Inferred from Sequence Orthology
more info
 
response to salt stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEDD4-like
Names
HECT-type E3 ubiquitin transferase NED4L
NEDD4.2
neural precursor cell expressed, developmentally down-regulated gene 4b
NP_001107858.1
NP_114087.2
XP_006526433.1
XP_006526434.1
XP_006526436.1
XP_006526437.1
XP_006526439.1
XP_006526440.1
XP_006526441.1
XP_006526442.1
XP_006526443.1
XP_006526445.1
XP_011245346.1
XP_011245349.1
XP_017173504.1
XP_017173505.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114386.1NP_001107858.1  E3 ubiquitin-protein ligase NEDD4-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC131709, AC161175
    Consensus CDS
    CCDS50309.1
    UniProtKB/TrEMBL
    E9PXB7
    Related
    ENSMUSP00000132838.1, ENSMUST00000163516.7
    Conserved Domains (6) summary
    cd04033
    Location:21153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:550582
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:643972
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:619973
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:501531
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:388417
    WW; WW domain
  2. NM_031881.2NP_114087.2  E3 ubiquitin-protein ligase NEDD4-like isoform 2

    See identical proteins and their annotated locations for NP_114087.2

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC161175
    Consensus CDS
    CCDS29305.1
    UniProtKB/TrEMBL
    G3X9H8
    Related
    ENSMUSP00000079280.4, ENSMUST00000080418.5
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    64887683..65217826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247044.2XP_011245346.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_011245346.1

    UniProtKB/TrEMBL
    G3X9H8
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  2. XM_011247047.2XP_011245349.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    UniProtKB/TrEMBL
    A0A286YCM8
    Conserved Domains (6) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:478832
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:360390
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  3. XM_006526373.3XP_006526436.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

    Conserved Domains (6) summary
    cd04033
    Location:21153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:530562
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:623952
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:599953
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:481511
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:368397
    WW; WW domain
  4. XM_006526374.3XP_006526437.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

    See identical proteins and their annotated locations for XP_006526437.1

    Conserved Domains (6) summary
    cd04033
    Location:8140
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:537569
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:630959
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:606960
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:488518
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:375404
    WW; WW domain
  5. XM_006526382.3XP_006526445.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_006526445.1

    UniProtKB/TrEMBL
    G3X9H8
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  6. XM_006526376.3XP_006526439.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_006526439.1

    UniProtKB/TrEMBL
    G3X9H8
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  7. XM_006526377.3XP_006526440.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_006526440.1

    UniProtKB/TrEMBL
    G3X9H8
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  8. XM_017318015.1XP_017173504.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    UniProtKB/TrEMBL
    A0A286YCM8
    Related
    ENSMUSP00000153052.1, ENSMUST00000224347.1
    Conserved Domains (6) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:478832
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:360390
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  9. XM_006526370.3XP_006526433.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

    Conserved Domains (6) summary
    cd04033
    Location:67179
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:576608
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:669998
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:645999
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:527557
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:414443
    WW; WW domain
  10. XM_006526371.3XP_006526434.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

    Conserved Domains (6) summary
    cd04033
    Location:67179
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:556588
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:649978
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:625979
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:507537
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:394423
    WW; WW domain
  11. XM_006526378.2XP_006526441.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_006526441.1

    UniProtKB/TrEMBL
    G3X9H8
    Related
    ENSMUSP00000153526.1, ENSMUST00000226058.1
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  12. XM_006526379.3XP_006526442.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_006526442.1

    UniProtKB/TrEMBL
    G3X9H8
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  13. XM_017318016.1XP_017173505.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    UniProtKB/TrEMBL
    A0A286YCM8
    Conserved Domains (6) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:478832
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:360390
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  14. XM_006526380.2XP_006526443.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    See identical proteins and their annotated locations for XP_006526443.1

    UniProtKB/TrEMBL
    G3X9H8
    Conserved Domains (6) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:498852
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:380410
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain

RNA

  1. XR_001782406.1 RNA Sequence

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