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Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like [ Mus musculus (house mouse) ]

Gene ID: 83814, updated on 21-Feb-2023

Summary

Official Symbol
Nedd4lprovided by MGI
Official Full Name
neural precursor cell expressed, developmentally down-regulated gene 4-likeprovided by MGI
Primary source
MGI:MGI:1933754
See related
Ensembl:ENSMUSG00000024589 AllianceGenome:MGI:1933754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nedd4b; NEDD4.2; Nedd4-2; 1300012C07Rik
Summary
Enables sodium channel inhibitor activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of ion transport. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E18 (RPKM 4.7) and 26 other tissues See more
Orthologs
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Genomic context

See Nedd4l in Genome Data Viewer
Location:
18; 18 E1
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (65017551..65350897)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64884480..65217826)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29860 Neighboring gene predicted gene, 46639 Neighboring gene predicted gene, 41756 Neighboring gene uncharacterized LOC118568359 Neighboring gene microRNA 122 Neighboring gene alpha-kinase 2 Neighboring gene predicted gene, 41757

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of bicellular tight junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEDD4-like
Names
HECT-type E3 ubiquitin transferase NED4L
neural precursor cell expressed, developmentally down-regulated gene 4b
NP_001107858.1
NP_114087.2
XP_006526433.1
XP_006526434.1
XP_006526436.1
XP_011245346.1
XP_011245349.1
XP_017173504.1
XP_017173505.1
XP_030106497.1
XP_030106501.1
XP_030106502.1
XP_030106503.1
XP_030106504.1
XP_036017204.1
XP_036017205.1
XP_036017206.1
XP_036017207.1
XP_036017208.1
XP_036017209.1
XP_036017210.1
XP_036017211.1
XP_036017212.1
XP_036017213.1
XP_036017214.1
XP_036017215.1
XP_036017216.1
XP_036017217.1
XP_036017218.1
XP_036017219.1
XP_036017220.1
XP_036017221.1
XP_036017222.1
XP_036017223.1
XP_036017224.1
XP_036017225.1
XP_036017226.1
XP_036017227.1
XP_036017228.1
XP_036017229.1
XP_036017230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114386.2NP_001107858.1  E3 ubiquitin-protein ligase NEDD4-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC131709, AC161175
    Consensus CDS
    CCDS50309.1
    UniProtKB/TrEMBL
    A0A494BAG2, E9PXB7
    Related
    ENSMUSP00000158026.2, ENSMUST00000235343.2
    Conserved Domains (6) summary
    cd04033
    Location:21153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:550582
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:643972
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:619973
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:501531
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:388417
    WW; WW domain
  2. NM_001404007.1NP_001390936.1  E3 ubiquitin-protein ligase NEDD4-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC131709, AC161175
    UniProtKB/TrEMBL
    A0A494B953
  3. NM_001404008.1NP_001390937.1  E3 ubiquitin-protein ligase NEDD4-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC161175
    UniProtKB/TrEMBL
    E9PXB7
  4. NM_001404009.1NP_001390938.1  E3 ubiquitin-protein ligase NEDD4-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC161175
    UniProtKB/TrEMBL
    E9PXB7
  5. NM_001404013.1NP_001390942.1  E3 ubiquitin-protein ligase NEDD4-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC161175
  6. NM_031881.3NP_114087.2  E3 ubiquitin-protein ligase NEDD4-like isoform 2

    See identical proteins and their annotated locations for NP_114087.2

    Status: VALIDATED

    Source sequence(s)
    AC102288, AC102333, AC161175
    Consensus CDS
    CCDS29305.1
    UniProtKB/TrEMBL
    A0A286YCM8, G3X9H8
    Related
    ENSMUSP00000079280.5, ENSMUST00000080418.7
    Conserved Domains (4) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    65017551..65350897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161323.1XP_036017216.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  2. XM_036161333.1XP_036017226.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

    Conserved Domains (4) summary
    smart00456
    Location:409459
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:520849
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  3. XM_030250641.1XP_030106501.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    E9PXB7
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  4. XM_036161325.1XP_036017218.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  5. XM_036161334.1XP_036017227.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

    Conserved Domains (4) summary
    smart00456
    Location:409459
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:520849
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  6. XM_030250643.1XP_030106503.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    E9PXB7
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  7. XM_036161324.1XP_036017217.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  8. XM_036161332.1XP_036017225.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

    Conserved Domains (4) summary
    smart00456
    Location:409459
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:520849
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  9. XM_030250642.1XP_030106502.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    E9PXB7
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  10. XM_036161336.1XP_036017229.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

    Conserved Domains (4) summary
    smart00456
    Location:259291
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:352681
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:77103
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  11. XM_036161321.1XP_036017214.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

    Conserved Domains (4) summary
    cd04033
    Location:8140
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:537587
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:648977
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:375404
    WW; WW domain
  12. XM_036161322.1XP_036017215.1  E3 ubiquitin-protein ligase NEDD4-like isoform X15

    Conserved Domains (4) summary
    cd04033
    Location:8140
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:517567
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:628957
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:355384
    WW; WW domain
  13. XM_030250637.1XP_030106497.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

    Conserved Domains (4) summary
    cd04033
    Location:8140
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:517549
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:610939
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:355384
    WW; WW domain
  14. XM_036161326.1XP_036017219.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  15. XM_036161320.1XP_036017213.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

    Conserved Domains (4) summary
    cd04033
    Location:14146
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:543593
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:654983
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:381410
    WW; WW domain
  16. XM_036161327.1XP_036017220.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  17. XM_011247044.3XP_011245346.1  E3 ubiquitin-protein ligase NEDD4-like isoform X18

    See identical proteins and their annotated locations for XP_011245346.1

    UniProtKB/TrEMBL
    A0A286YCM8, G3X9H8
    Conserved Domains (4) summary
    smart00456
    Location:429461
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:522851
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  18. XM_036161335.1XP_036017228.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

    Conserved Domains (4) summary
    smart00456
    Location:409459
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:520849
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  19. XM_011247047.3XP_011245349.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    A0A286YCM8, E9PXB7
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  20. XM_036161318.1XP_036017211.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

    Conserved Domains (4) summary
    cd04033
    Location:21153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:550600
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:661990
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:388417
    WW; WW domain
  21. XM_036161319.1XP_036017212.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

    Conserved Domains (4) summary
    cd04033
    Location:21153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:530580
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:641970
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:368397
    WW; WW domain
  22. XM_006526373.3XP_006526436.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

    Related
    ENSMUSP00000157490.2, ENSMUST00000236736.2
    Conserved Domains (4) summary
    cd04033
    Location:21153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:530562
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:623952
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:368397
    WW; WW domain
  23. XM_036161328.1XP_036017221.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  24. XM_017318015.2XP_017173504.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    A0A286YCM8
    Related
    ENSMUSP00000157910.2, ENSMUST00000237854.2
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  25. XM_006526370.4XP_006526433.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

    Conserved Domains (4) summary
    cd04033
    Location:67179
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:576608
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:669998
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:414443
    WW; WW domain
  26. XM_036161317.1XP_036017210.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

    Conserved Domains (4) summary
    cd04033
    Location:67179
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:556606
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:667996
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:394423
    WW; WW domain
  27. XM_006526371.4XP_006526434.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

    Conserved Domains (4) summary
    cd04033
    Location:67179
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:556588
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:649978
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:394423
    WW; WW domain
  28. XM_036161337.1XP_036017230.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

    Related
    ENSMUSP00000157658.2, ENSMUST00000236103.2
    Conserved Domains (4) summary
    smart00456
    Location:259291
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:352681
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:77103
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  29. XM_036161329.1XP_036017222.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  30. XM_030250644.2XP_030106504.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    Related
    ENSMUSP00000132838.3, ENSMUST00000163516.9
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  31. XM_036161330.1XP_036017223.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  32. XM_017318016.2XP_017173505.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

    UniProtKB/TrEMBL
    A0A286YCM8, E9PXB7
    Conserved Domains (4) summary
    smart00456
    Location:409441
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:502831
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:247276
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain
  33. XM_036161315.1XP_036017208.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    Conserved Domains (5) summary
    smart00456
    Location:647697
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:7581087
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:83316
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00397
    Location:465491
    WW; WW domain
    cl14603
    Location:367420
    C2; C2 domain
  34. XM_036161316.1XP_036017209.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    Conserved Domains (5) summary
    smart00456
    Location:647679
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:7401069
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:83316
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00397
    Location:465491
    WW; WW domain
    cl14603
    Location:367420
    C2; C2 domain
  35. XM_036161311.1XP_036017204.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

    Conserved Domains (6) summary
    smart00456
    Location:817867
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9281257
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03378
    Location:107318
    PHA03378; EBNA-3B; Provisional
    cd00201
    Location:768798
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:655684
    WW; WW domain
    cl14603
    Location:367420
    C2; C2 domain
  36. XM_036161312.1XP_036017205.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

    Conserved Domains (6) summary
    smart00456
    Location:817849
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9101239
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03378
    Location:107318
    PHA03378; EBNA-3B; Provisional
    cd00201
    Location:768798
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:655684
    WW; WW domain
    cl14603
    Location:367420
    C2; C2 domain
  37. XM_036161313.1XP_036017206.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

    Conserved Domains (6) summary
    smart00456
    Location:797847
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9081237
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:83316
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:748778
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:635664
    WW; WW domain
    cl14603
    Location:367420
    C2; C2 domain
  38. XM_036161314.1XP_036017207.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

    Conserved Domains (6) summary
    smart00456
    Location:797829
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:8901219
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03307
    Location:83316
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00201
    Location:748778
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:635664
    WW; WW domain
    cl14603
    Location:367420
    C2; C2 domain
  39. XM_036161331.1XP_036017224.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

    Conserved Domains (4) summary
    smart00456
    Location:429479
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:540869
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:267296
    WW; WW domain
    cl14603
    Location:132
    C2; C2 domain