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Vegfa vascular endothelial growth factor A [ Rattus norvegicus (Norway rat) ]

Gene ID: 83785, updated on 2-May-2024

Summary

Official Symbol
Vegfaprovided by RGD
Official Full Name
vascular endothelial growth factor Aprovided by RGD
Primary source
RGD:619991
See related
Ensembl:ENSRNOG00000019598 AllianceGenome:RGD:619991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
VPF; Vegf; VEGF-A; VEGF111; VEGF164
Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Expression
Biased expression in Lung (RPKM 1035.8), Heart (RPKM 646.4) and 8 other tissues See more
Orthologs
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Genomic context

See Vegfa in Genome Data Viewer
Location:
9q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22452854..22468194)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14955300..14970641)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17340341..17355681)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480341 Neighboring gene uncharacterized LOC134480342 Neighboring gene uncharacterized LOC134480343 Neighboring gene uncharacterized LOC102550162

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
enables chemoattractant activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables neuropilin binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor 2 binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vascular endothelial growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in VEGF-activated neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in angiogenesis involved in coronary vascular morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in basophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone trabecula formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac vascular smooth muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estrogen stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to wortmannin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular stress response to acid chemical IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular stress response to acid chemical ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary vein morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within eye photoreceptor cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in induction of positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in lymph vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of adherens junction organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of trophoblast cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nitric oxide mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxygen levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
NOT involved_in retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue remodeling IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in tube formation IEA
Inferred from Electronic Annotation
more info
 
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in tube formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor-2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor-2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of VEGF-A complex IEA
Inferred from Electronic Annotation
more info
 
part_of VEGF-A complex ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor A
Names
vascular permeability factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110333.2NP_001103803.1  vascular endothelial growth factor A isoform 2

    See identical proteins and their annotated locations for NP_001103803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame, internal coding exon, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (2) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K6Z7, B5DEK7
    Conserved Domains (2) summary
    smart00141
    Location:228310
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:316369
    VEGF_C; VEGF heparin-binding domain
  2. NM_001110334.2NP_001103804.1  vascular endothelial growth factor A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (3) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF215726, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    F8WG85
    Conserved Domains (1) summary
    smart00141
    Location:228310
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  3. NM_001110335.1NP_001103805.1  vascular endothelial growth factor A isoform 4

    See identical proteins and their annotated locations for NP_001103805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. This variant has transcript support, but the protein is predicted.
    Source sequence(s)
    BQ203400, CK357826, CK358638, CK364938, CK602714, CV107730
    UniProtKB/TrEMBL
    A6JIV9, Q63672, Q63882
    Conserved Domains (2) summary
    pfam14554
    Location:61109
    VEGF_C; VEGF heparin-binding domain
    cl00116
    Location:126
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  4. NM_001110336.1NP_001103806.1  vascular endothelial growth factor A isoform 5

    See identical proteins and their annotated locations for NP_001103806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region and an in-frame, internal coding exon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus and lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.
    Source sequence(s)
    BQ203400, CK357826, CK358638, CK364938, CK602714, CV107730
    UniProtKB/TrEMBL
    A6JIW0, B4XHA2
    Conserved Domains (2) summary
    pfam14554
    Location:3285
    VEGF_C; VEGF heparin-binding domain
    cl00116
    Location:126
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  5. NM_001287107.1NP_001274036.1  vascular endothelial growth factor A isoform 6 precursor

    See identical proteins and their annotated locations for NP_001274036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (6) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF215725, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P16612, Q541S6, Q91ZE1, Q9JKX7, Q9QXG6, Q9QXG7
    UniProtKB/TrEMBL
    A0A8I5ZN58, A6JIU4
    Conserved Domains (2) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:166214
    VEGF_C; VEGF heparin-binding domain
  6. NM_001287108.1NP_001274037.1  vascular endothelial growth factor A isoform Vegf-A precursor

    See identical proteins and their annotated locations for NP_001274037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame, internal coding exon compared to variant 1. It can initiate translation from a non-AUG (CUG) codon, and also from an in-frame, downstream AUG start codon. The isoform (Vegf-A) represented in this RefSeq is derived from the AUG start codon. It has a shorter N-terminus and lacks an internal protein segment compared to isoform 1. This variant also encodes a C-terminally extended isoform (Vegf-Ax), which results from the use of an alternative in-frame, downstream translation termination codon (UAA). Isoform Vegf-Ax is represented in NM_001317043.1.
    Source sequence(s)
    BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JIU7, C9DRV0
    Conserved Domains (2) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:137190
    VEGF_C; VEGF heparin-binding domain
  7. NM_001287110.1NP_001274039.1  vascular endothelial growth factor A isoform 8 precursor

    See identical proteins and their annotated locations for NP_001274039.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (8) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF215726, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    Q541S7, Q64FZ6
    Related
    ENSRNOP00000050127.3, ENSRNOT00000044163.5
    Conserved Domains (1) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  8. NM_001287111.1NP_001274040.1  vascular endothelial growth factor A isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame, internal exon in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (9) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF222779, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0H2UHY5
    Related
    ENSRNOP00000047820.3, ENSRNOT00000042790.4
    Conserved Domains (1) summary
    smart00141
    Location:228310
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  9. NM_001287112.1NP_001274041.1  vascular endothelial growth factor A isoform 10 precursor

    See identical proteins and their annotated locations for NP_001274041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame, internal exon in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (10) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF222779, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    Q64FZ6
    Conserved Domains (1) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  10. NM_001287113.1NP_001274042.1  vascular endothelial growth factor A isoform 11

    See identical proteins and their annotated locations for NP_001274042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG site, and an in-frame, internal coding exon, compared to variant 1. The resulting isoform (11) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AY378102, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JIV1, C9DRV0
    Conserved Domains (2) summary
    smart00141
    Location:789
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:95148
    VEGF_C; VEGF heparin-binding domain
  11. NM_001287114.1NP_001274043.1  vascular endothelial growth factor A isoform 12

    See identical proteins and their annotated locations for NP_001274043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG site, and two consecutive in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (12) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF215726, AY378102, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JIV5
    Conserved Domains (1) summary
    smart00141
    Location:789
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  12. NM_001317043.1NP_001303972.1  vascular endothelial growth factor A isoform Vegf-Ax precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is identical to NM_001287108.1; however, it uses an alternative in-frame, downstream translation termination codon (UAA), which results in a longer, C-terminally extended isoform (Vegf-Ax) compared to isoform Vegf-A. Unlike isoform Vegf-A, which is proangiogenic, Vegf-Ax exhibits antiangiogenic activity. As the upstream UGA stop codon has been shown to be recoded as serine (PMID:24949972), its location in the Vegf-Ax isoform (aa 191) is denoted by an 'S'.
    Source sequence(s)
    BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    B5DEK7
    Conserved Domains (2) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:142190
    VEGF_C; VEGF heparin-binding domain
  13. NM_031836.3NP_114024.2  vascular endothelial growth factor A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (1) represented in this RefSeq is derived from the CUG start codon and it is the longest isoform.
    Source sequence(s)
    AF215725, BC168708, CO565920, JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0H2UHY5
    Related
    ENSRNOP00000026637.5, ENSRNOT00000026637.8
    Conserved Domains (1) summary
    smart00141
    Location:228310
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RNA

  1. NR_105011.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate splice site and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY702972, BC168708, CO565920, JAXUCZ010000009
    Related
    ENSRNOT00000026559.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    22452854..22468194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)