Vegfa vascular endothelial growth factor A [ Rattus norvegicus (Norway rat) ]

Gene ID: 83785, updated on 6-Jan-2019

Summary

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Official Symbol: Vegfaprovided by RGD
Official Full Name: vascular endothelial growth factor Aprovided by RGD
Primary source: RGD:619991
See related: Ensembl:ENSRNOG00000019598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: VPF; Vegf; VEGF-A; VEGF111; VEGF164
Summary: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Expression: Biased expression in Lung (RPKM 1035.8), Heart (RPKM 646.4) and 8 other tissues See more
Orthologs: human mouse all

Genomic context

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See Vegfa in Genome Data Viewer

Location:: 9q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (17340341..17355681)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	9	NC_005108.3 (16232415..16247658)

Chromosome 9 - NC_005108.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Our main findings demonstrate that 2-h swim exercise rapidly (i.e., immediately postexercise) increased Vegf-a mRNA levels in both subcutaneous (iWAT) and intra-abdominal (eWAT, rpWAT) adipose tissue of male Wistar rats after 2 weeks of high fat diet but not in rats kept on low fat diet.
Title: Acute endurance exercise increases Vegfa mRNA expression in adipose tissue of rats during the early stages of weight gain.
the epigenetic mechanisms involved in the physical exercise-mediated induction of VegfA expression, were examined.
Title: Voluntary Physical Exercise Induces Expression and Epigenetic Remodeling of VegfA in the Rat Hippocampus.
Our data suggest that activation of the GPR91-ERK1/2-C/EBP beta (c-Fos, HIF-1a) signaling pathway plays a tonic role in regulating VEGF transcription in rat retinal ganglion cells.
Title: Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
present results suggested that pathologically high cyclic stretch induces the shuttling of SRSF1 which results in the secretive pattern splicing of VEGFA and finally contributes to the proliferation of vascular smooth muscle cells.
Title: Cyclic stretch induces VEGFA alternative splicing via Serine/Arginine-Rich Splicing Factor 1.
overexpression of decorin ameliorated diabetic cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF signaling pathway in vivo and in vitro.
Title: Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling.
In conclusion, Thymosin beta4 significantly increased angiogenesis by enhancing the paracrine effects of Endothelial progenitor cells (EPCs), evidenced by the increased expression of VEGF
Title: Thymosin β4 promotes endothelial progenitor cell angiogenesis via a vascular endothelial growth factor‑dependent mechanism.
Results indicate that vascular endothelial growth factor (VEGF) is a vital important factor that contributes to the small-airway remodelling in a rat model of Chronic obstructive pulmonary disease through promoting angiogenesis, which mainly depend on the specific binding between VEGF and VEGF receptor 1 and can be effectively attenuated by sunitinib.
Title: The Role of Vascular Endothelial Growth Factor in Small-airway Remodelling in a Rat Model of Chronic Obstructive Pulmonary Disease.
150-kDa oxygen-regulated protein (ORP150) levels were significantly increased in rat retinas after induction of diabetes. Vascular endothelial growth factor (VEGF) and the pro-inflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) induced upregulation of ORP150 in HRMEC.
Title: Association of 150-kDa oxygen-regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy.
Expression of vascular endothelial growth factor in cardiac repair: Signaling mechanisms mediating vascular protective effects
Title: Expression of vascular endothelial growth factor in cardiac repair: Signaling mechanisms mediating vascular protective effects.
IL10 suppressed inflammation, facilitated retinal pigment epithelium cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression in rhegmatogenous retinal detachment.
Title: IL-10 inhibits retinal pigment epithelium cell proliferation and migration through regulation of VEGF in rhegmatogenous retinal detachment.

Submit: New GeneRIF Correction See all GeneRIFs (524)

Variation

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Pathways from BioSystems

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AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Bladder cancer, organism-specific biosystem (from KEGG)
Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Bladder cancer, conserved biosystem (from KEGG)
Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
EPH-Ephrin signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
EPHA-mediated growth cone collapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Endochondral Ossification, organism-specific biosystem (from WikiPathways)
Endochondral Ossification, organism-specific biosystem
Endochondral Ossification
Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hypertrophy Model, organism-specific biosystem (from WikiPathways)
Hypertrophy Model, organism-specific biosystem
Hypertrophy Model
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
MicroRNAs in cancer, organism-specific biosystem (from KEGG)
MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
MicroRNAs in cancer, conserved biosystem (from KEGG)
MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pancreatic cancer, organism-specific biosystem (from KEGG)
Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pancreatic cancer, conserved biosystem (from KEGG)
Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Rap1 signaling pathway, organism-specific biosystem (from KEGG)
Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Rap1 signaling pathway, conserved biosystem (from KEGG)
Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Ras signaling pathway, organism-specific biosystem (from KEGG)
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
VEGF ligand-receptor interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGF signaling pathway, organism-specific biosystem (from KEGG)
VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGF signaling pathway, conserved biosystem (from KEGG)
VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGF-receptor Signal Transduction, organism-specific biosystem (from WikiPathways)
VEGF-receptor Signal Transduction, organism-specific biosystemVEGF Signal transduction in haematopoeitic stem cells, macrophages, monocyten, vascular endothelium and lymphatic endothelium.
VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
VEGFA-VEGFR2 Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
VEGFR2 mediated cell proliferation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vegfa (e-PCR), detects polymorphism
- UniSTS:471318

Vegfa (e-PCR), detects polymorphism
- UniSTS:462632

PMC20712P1 (e-PCR)
- UniSTS:271944

VEGF_1127 (e-PCR)
- UniSTS:277860

VEGF_V308 (e-PCR)
- UniSTS:277860

Vegf (e-PCR), detects polymorphism
- UniSTS:144751

Vegf (e-PCR), detects polymorphism
- UniSTS:181878

D2Wox60 (e-PCR)
- UniSTS:240057

D2Wox61 (e-PCR)
- UniSTS:240058

Homology

Homologs of the Vegfa gene: The Vegfa gene is conserved in human, dog, cow, mouse, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 246 organisms have orthologs with human gene Vegfa
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
chemoattractant activity	IMP Inferred from Mutant Phenotype more info	PubMed
chemoattractant activity	ISO Inferred from Sequence Orthology more info
cytokine activity	ISO Inferred from Sequence Orthology more info
extracellular matrix binding	ISO Inferred from Sequence Orthology more info
fibronectin binding	ISO Inferred from Sequence Orthology more info
growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
growth factor activity	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	IEA Inferred from Electronic Annotation more info
growth factor activity	ISO Inferred from Sequence Orthology more info
growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
heparin binding	IEA Inferred from Electronic Annotation more info
heparin binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
neuropilin binding	ISO Inferred from Sequence Orthology more info
platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
receptor ligand activity	ISO Inferred from Sequence Orthology more info
signaling receptor binding	ISO Inferred from Sequence Orthology more info
vascular endothelial growth factor receptor 1 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vascular endothelial growth factor receptor 1 binding	ISO Inferred from Sequence Orthology more info
vascular endothelial growth factor receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vascular endothelial growth factor receptor 2 binding	IMP Inferred from Mutant Phenotype more info	PubMed
vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info
vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vascular endothelial growth factor receptor binding	ISO Inferred from Sequence Orthology more info
vascular endothelial growth factor receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
VEGF-activated neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
aging	IEP Inferred from Expression Pattern more info	PubMed
angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis	ISO Inferred from Sequence Orthology more info
angiogenesis	TAS Traceable Author Statement more info	PubMed
angiogenesis involved in coronary vascular morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
artery morphogenesis	ISO Inferred from Sequence Orthology more info
basophil chemotaxis	ISO Inferred from Sequence Orthology more info
blood vessel development	ISO Inferred from Sequence Orthology more info
blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
bone trabecula formation	ISO Inferred from Sequence Orthology more info
bone trabecula morphogenesis	ISO Inferred from Sequence Orthology more info
branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
cardiac muscle fiber development	ISO Inferred from Sequence Orthology more info
cardiac vascular smooth muscle cell development	ISO Inferred from Sequence Orthology more info
cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
cell maturation	ISO Inferred from Sequence Orthology more info
cell migration	ISO Inferred from Sequence Orthology more info
cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
cell proliferation	ISO Inferred from Sequence Orthology more info
cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to drug	IEP Inferred from Expression Pattern more info	PubMed
cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
cellular stress response to acid chemical	ISO Inferred from Sequence Orthology more info
commissural neuron axon guidance	ISO Inferred from Sequence Orthology more info
NOT commissural neuron axon guidance	ISO Inferred from Sequence Orthology more info
coronary artery morphogenesis	ISO Inferred from Sequence Orthology more info
coronary vein morphogenesis	ISO Inferred from Sequence Orthology more info
dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
endothelial cell migration	ISO Inferred from Sequence Orthology more info
epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
eye photoreceptor cell development	ISO Inferred from Sequence Orthology more info
female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
heart morphogenesis	ISO Inferred from Sequence Orthology more info
homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
hyaluronan metabolic process	IEP Inferred from Expression Pattern more info	PubMed
in utero embryonic development	ISO Inferred from Sequence Orthology more info
induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
kidney development	ISO Inferred from Sequence Orthology more info
lactation	ISO Inferred from Sequence Orthology more info
lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
lung development	ISO Inferred from Sequence Orthology more info
lung vasculature development	ISO Inferred from Sequence Orthology more info
lymph vessel morphogenesis	ISO Inferred from Sequence Orthology more info
lymphangiogenesis	ISO Inferred from Sequence Orthology more info
mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
macrophage differentiation	ISO Inferred from Sequence Orthology more info
mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
mesoderm development	ISO Inferred from Sequence Orthology more info
monocyte differentiation	ISO Inferred from Sequence Orthology more info
motor neuron migration	ISO Inferred from Sequence Orthology more info
motor neuron migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of neuron death	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
nervous system development	IDA Inferred from Direct Assay more info	PubMed
nervous system development	NAS Non-traceable Author Statement more info	PubMed
neuron development	ISO Inferred from Sequence Orthology more info
outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
ovarian follicle development	ISO Inferred from Sequence Orthology more info
positive chemotaxis	IEA Inferred from Electronic Annotation more info
positive chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
NOT positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of cellular component movement	ISO Inferred from Sequence Orthology more info
positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
positive regulation of histone deacetylase activity	ISO Inferred from Sequence Orthology more info
positive regulation of lymphangiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein complex assembly	ISO Inferred from Sequence Orthology more info
positive regulation of protein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein kinase B signaling	ISO Inferred from Sequence Orthology more info
positive regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
positive regulation of protein kinase D signaling	ISO Inferred from Sequence Orthology more info
positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
positive regulation of retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
positive regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	ISO Inferred from Sequence Orthology more info
NOT positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
post-embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
primitive erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
regulation of cell shape	ISO Inferred from Sequence Orthology more info
regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
regulation of growth	ISO Inferred from Sequence Orthology more info
regulation of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
regulation of nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
regulation of retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
NOT regulation of retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
regulation of signaling receptor activity	IEA Inferred from Electronic Annotation more info
regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
response to cold	IEP Inferred from Expression Pattern more info	PubMed
response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
response to folic acid	IEP Inferred from Expression Pattern more info	PubMed
response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	ISO Inferred from Sequence Orthology more info
response to oxygen levels	IEP Inferred from Expression Pattern more info	PubMed
response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
retinal blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
surfactant homeostasis	ISO Inferred from Sequence Orthology more info
tube formation	ISO Inferred from Sequence Orthology more info
tube formation	ISS Inferred from Sequence or Structural Similarity more info
vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
vasculature development	ISO Inferred from Sequence Orthology more info
wound healing	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
basement membrane	IDA Inferred from Direct Assay more info	PubMed
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info
secretory granule	ISO Inferred from Sequence Orthology more info
vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor A

Names: vascular permeability factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110333.2 → NP_001103803.1 vascular endothelial growth factor A isoform 2

See identical proteins and their annotated locations for NP_001103803.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame, internal coding exon, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (2) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, BC168708, CO565920

UniProtKB/TrEMBL

B5DEK7

Related

ENSRNOP00000026559.3, ENSRNOT00000026559.5

Conserved Domains (2) summary

smart00141
Location:228 → 310

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:316 → 369

VEGF_C; VEGF heparin-binding domain
NM_001110334.2 → NP_001103804.1 vascular endothelial growth factor A isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (3) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, AF215726, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Related

ENSRNOP00000050127.2, ENSRNOT00000044163.4

Conserved Domains (1) summary

smart00141
Location:228 → 310

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001110335.1 → NP_001103805.1 vascular endothelial growth factor A isoform 4

See identical proteins and their annotated locations for NP_001103805.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. This variant has transcript support, but the protein is predicted.

Source sequence(s)

BQ203400, CK357826, CK358638, CK364938, CK602714, CV107730

Conserved Domains (2) summary

pfam14554
Location:61 → 109

VEGF_C; VEGF heparin-binding domain

cl00116
Location:1 → 26

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001110336.1 → NP_001103806.1 vascular endothelial growth factor A isoform 5

See identical proteins and their annotated locations for NP_001103806.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region and an in-frame, internal coding exon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus and lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.

Source sequence(s)

BQ203400, CK357826, CK358638, CK364938, CK602714, CV107730

Conserved Domains (2) summary

pfam14554
Location:32 → 85

VEGF_C; VEGF heparin-binding domain

cl00116
Location:1 → 26

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001287107.1 → NP_001274036.1 vascular endothelial growth factor A isoform 6 precursor

See identical proteins and their annotated locations for NP_001274036.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (6) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC108326, AF215725, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:166 → 214

VEGF_C; VEGF heparin-binding domain
NM_001287108.1 → NP_001274037.1 vascular endothelial growth factor A isoform Vegf-A precursor

See identical proteins and their annotated locations for NP_001274037.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame, internal coding exon compared to variant 1. It can initiate translation from a non-AUG (CUG) codon, and also from an in-frame, downstream AUG start codon. The isoform (Vegf-A) represented in this RefSeq is derived from the AUG start codon. It has a shorter N-terminus and lacks an internal protein segment compared to isoform 1. This variant also encodes a C-terminally extended isoform (Vegf-Ax), which results from the use of an alternative in-frame, downstream translation termination codon (UAA). Isoform Vegf-Ax is represented in NM_001317043.1.

Source sequence(s)

AC108326, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:137 → 190

VEGF_C; VEGF heparin-binding domain
NM_001287110.1 → NP_001274039.1 vascular endothelial growth factor A isoform 8 precursor

See identical proteins and their annotated locations for NP_001274039.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (8) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, AF215726, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7, Q541S7

Conserved Domains (1) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001287111.1 → NP_001274040.1 vascular endothelial growth factor A isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an in-frame, internal exon in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (9) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, AF222779, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Related

ENSRNOP00000047820.3, ENSRNOT00000042790.3

Conserved Domains (1) summary

smart00141
Location:228 → 310

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001287112.1 → NP_001274041.1 vascular endothelial growth factor A isoform 10 precursor

See identical proteins and their annotated locations for NP_001274041.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an in-frame, internal exon in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (10) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, AF222779, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Conserved Domains (1) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001287113.1 → NP_001274042.1 vascular endothelial growth factor A isoform 11

See identical proteins and their annotated locations for NP_001274042.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG site, and an in-frame, internal coding exon, compared to variant 1. The resulting isoform (11) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, AY378102, BC168708, CO565920

UniProtKB/TrEMBL

A0A0G2K6Z7, B5DEK7

Related

ENSRNOP00000074002.1, ENSRNOT00000083811.1

Conserved Domains (2) summary

smart00141
Location:7 → 89

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:95 → 148

VEGF_C; VEGF heparin-binding domain
NM_001287114.1 → NP_001274043.1 vascular endothelial growth factor A isoform 12

See identical proteins and their annotated locations for NP_001274043.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG site, and two consecutive in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (12) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC108326, AF215726, AY378102, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Conserved Domains (1) summary

smart00141
Location:7 → 89

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
NM_001317043.1 → NP_001303972.1 vascular endothelial growth factor A isoform Vegf-Ax precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) is identical to NM_001287108.1; however, it uses an alternative in-frame, downstream translation termination codon (UAA), which results in a longer, C-terminally extended isoform (Vegf-Ax) compared to isoform Vegf-A. Unlike isoform Vegf-A, which is proangiogenic, Vegf-Ax exhibits antiangiogenic activity. As the upstream UGA stop codon has been shown to be recoded as serine (PMID:24949972), its location in the Vegf-Ax isoform (aa 191) is denoted by an 'S'.

Source sequence(s)

AC108326, BC168708, CO565920

UniProtKB/TrEMBL

B5DEK7

Conserved Domains (2) summary

smart00141
Location:49 → 131

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:137 → 190

VEGF_C; VEGF heparin-binding domain
NM_031836.3 → NP_114024.2 vascular endothelial growth factor A isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (1) represented in this RefSeq is derived from the CUG start codon and it is the longest isoform.

Source sequence(s)

AC108326, AF215725, BC168708, CO565920

UniProtKB/Swiss-Prot

P16612

UniProtKB/TrEMBL

B5DEK7

Related

ENSRNOP00000026637.4, ENSRNOT00000026637.7

Conserved Domains (2) summary

smart00141
Location:228 → 310

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:344 → 393

VEGF_C; VEGF heparin-binding domain

RNA

NR_105011.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) has an alternate splice site and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC108326, AY702972, BC168708, CO565920