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CLP2 CLP protease proteolytic subunit 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837797, updated on 15-Oct-2023

Summary

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Gene symbol
CLP2
Gene description
CLP protease proteolytic subunit 2
Primary source
Araport:AT1G12410
Locus tag
AT1G12410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CLP protease proteolytic subunit 2; CLPR2; EMB3146; EMBRYO DEFECTIVE 3146; F5O11.13; F5O11_13; NCLPP2; NUCLEAR-ENCODED CLP PROTEASE P2
Summary
Encodes a ClpP-related sequence. Though similar to ClpP proteins, this does not contains the highly conserved catalytic triad of Ser-type proteases (Ser-His-Asp). The name reflects nomenclature described in Adam et. al (2001).
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Sequence:
Chromosome: 1; NC_003070.9 (4223030..4225254)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cornichon family protein Neighboring gene Nucleotide excision repair, TFIIH, subunit TTDA Neighboring gene uncharacterized protein Neighboring gene ACT domain repeat 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Downregulation of ClpR2 leads to reduced accumulation of the ClpPRS protease complex and defects in chloroplast biogenesis in Arabidopsis. Rudella A, et al. Plant Cell, 2006 Jul. PMID 16766689, Free PMC Article
  2. Large scale comparative proteomics of a chloroplast Clp protease mutant reveals folding stress, altered protein homeostasis, and feedback regulation of metabolism. Zybailov B, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423572, Free PMC Article
  3. Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis. Kim J, et al. Plant Physiol, 2013 May. PMID 23548781, Free PMC Article
  4. Subunit stoichiometry, evolution, and functional implications of an asymmetric plant plastid ClpP/R protease complex in Arabidopsis. Olinares PD, et al. Plant Cell, 2011 Jun. PMID 21712416, Free PMC Article
  5. Identification of a 350-kDa ClpP protease complex with 10 different Clp isoforms in chloroplasts of Arabidopsis thaliana. Peltier JB, et al. J Biol Chem, 2001 May 11. PMID 11278690

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of the proteomics phenotype of clpp3-1 with the clpr2-1 and clpr4-1 phenotypes indicated very similar metabolic and protein homeostasis defects for these Clp core mutants.
    Title: Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis.
  2. Results show that proteomics data and the role of Clp provide testable hypotheses and putative substrates to further determine the significance of Clp-driven proteolysis.
    Title: Large scale comparative proteomics of a chloroplast Clp protease mutant reveals folding stress, altered protein homeostasis, and feedback regulation of metabolism.
  3. Data suggest that ClpR2 cannot be functionally replaced by other ClpP/R homologues and that the ClpPRS complex is central to chloroplast biogenesis, thylakoid protein homeostasis, and plant development.
    Title: Downregulation of ClpR2 leads to reduced accumulation of the ClpPRS protease complex and defects in chloroplast biogenesis in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_101113.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast thylakoid IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chloroplastic endopeptidase Clp complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region HDA PubMed 

General protein information

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Preferred Names
CLP protease proteolytic subunit 2
NP_563907.1
  • CLP protease proteolytic subunit 2 (CLP2); FUNCTIONS IN: serine-type endopeptidase activity; INVOLVED IN: chloroplast organization; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S14, ClpP (InterPro:IPR001907); BEST Arabidopsis thaliana protein match is: plastid-encoded CLP P (TAIR:ATCG00670.1); Has 13082 Blast hits to 13064 proteins in 2999 species: Archae - 2; Bacteria - 8275; Metazoa - 145; Fungi - 81; Plants - 1076; Viruses - 67; Other Eukaryotes - 3436 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4223030..4225254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101113.4 → NP_563907.1  CLP protease proteolytic subunit 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93ZD4, Q9XJ36
    UniProtKB/TrEMBL
    A0A178WNM1, A0A5S9U2M2
    Conserved Domains (1) summary
    pfam00574
    Location:86 → 262
    CLP_protease; Clp protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XJ36.1

Gene LinkOut

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