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Wasf1 WASP family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 83767, updated on 12-May-2024

Summary

Official Symbol
Wasf1provided by MGI
Official Full Name
WASP family, member 1provided by MGI
Primary source
MGI:MGI:1890563
See related
Ensembl:ENSMUSG00000019831 AllianceGenome:MGI:1890563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scar; WAVE; WAVE-1
Summary
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium; mitochondrial outer membrane; and postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 33.5), cortex adult (RPKM 31.9) and 9 other tissues See more
Orthologs
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Genomic context

See Wasf1 in Genome Data Viewer
Location:
10 B1; 10 22.07 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40759476..40814565)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40883480..40938569)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 24 Neighboring gene STARR-seq mESC enhancer starr_26430 Neighboring gene STARR-seq mESC enhancer starr_26431 Neighboring gene STARR-seq mESC enhancer starr_26432 Neighboring gene STARR-seq mESC enhancer starr_26433 Neighboring gene STARR-seq mESC enhancer starr_26435 Neighboring gene cell division cycle 40 Neighboring gene STARR-positive B cell enhancer ABC_E2320 Neighboring gene STARR-seq mESC enhancer starr_26437 Neighboring gene STARR-seq mESC enhancer starr_26438 Neighboring gene STARR-seq mESC enhancer starr_26439 Neighboring gene STARR-seq mESC enhancer starr_26440 Neighboring gene predicted gene, 48057 Neighboring gene predicted gene, 19611

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to brain-derived neurotrophic factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
actin-binding protein WASF1
Names
WAS protein family, member 1
WASP family 1
WASP family protein member 1
protein WAVE-1
wiskott-Aldrich syndrome protein family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379453.1NP_001366382.1  actin-binding protein WASF1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC174452
    UniProtKB/Swiss-Prot
    Q8R5H6, Q91W51, Q9ERQ9
    Related
    ENSMUSP00000101148.2, ENSMUST00000105509.2
    Conserved Domains (2) summary
    cd22071
    Location:485559
    WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)
    NF033761
    Location:394498
    gliding_GltJ; adventurous gliding motility protein GltJ
  2. NM_001379454.1NP_001366383.1  actin-binding protein WASF1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC174452
    Conserved Domains (2) summary
    cd22071
    Location:484558
    WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)
    NF033761
    Location:393497
    gliding_GltJ; adventurous gliding motility protein GltJ
  3. NM_031877.3NP_114083.1  actin-binding protein WASF1 isoform 1

    See identical proteins and their annotated locations for NP_114083.1

    Status: VALIDATED

    Source sequence(s)
    AF290877, BC053423, BY332208
    Consensus CDS
    CCDS23801.1
    UniProtKB/Swiss-Prot
    Q8R5H6, Q91W51, Q9ERQ9
    Related
    ENSMUSP00000019975.8, ENSMUST00000019975.14
    Conserved Domains (2) summary
    cd22071
    Location:485559
    WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)
    NF033761
    Location:394498
    gliding_GltJ; adventurous gliding motility protein GltJ

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40759476..40814565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245406.1XP_030101266.1  actin-binding protein WASF1 isoform X1

    Conserved Domains (2) summary
    cd22071
    Location:484558
    WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)
    NF033761
    Location:393497
    gliding_GltJ; adventurous gliding motility protein GltJ