Wasf1 WASP family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wasf1provided by MGI
Official Full Name: WASP family, member 1provided by MGI
Primary source: MGI:MGI:1890563
See related: Ensembl:ENSMUSG00000019831 AllianceGenome:MGI:1890563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Scar; WAVE; WAVE-1
Summary: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium; mitochondrial outer membrane; and postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 33.5), cortex adult (RPKM 31.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 22.07 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (40759476..40814565)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (40883480..40938569)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate a molecular protocadherin alpha (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain.
Title: Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.
WAVE-1 restoration improves maze exploration performance of GluN1 knockdown mice
Title: Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice.
Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine.
Title: WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.
We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP, whereas Src-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP
Title: Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.
WAVE1 phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA. WAVE1 overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin expression, and vice versa
Title: Cyclosporine A protects podocytes by regulating WAVE1 phosphorylation.
Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.
Title: Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.
Lpd directly binds active Rac, which regulates a direct interaction between Lpd and the Scar/WAVE complex
Title: Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.
An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.
Title: WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs.
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
Title: Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
WAVE accumulation may be involved in Abeta/amyloid precursor protein mediated-tangle modification
Title: Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135950 (e-PCR)
- UniSTS:209946

AI838537 (e-PCR)
- UniSTS:164435

1634 (e-PCR)
- UniSTS:49530

Wasf1 (e-PCR), detects polymorphism
- UniSTS:256992

Homology

Homologs of the Wasf1 gene: The Wasf1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 489 organisms have orthologs with human gene Wasf1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic transport of mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IPI Inferred from Physical Interaction more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin-binding protein WASF1; wiskott-Aldrich syndrome protein family member 1

Names: WAS protein family, member 1; WASP family 1; WASP family protein member 1; protein WAVE-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379453.1 → NP_001366382.1 actin-binding protein WASF1 isoform 1

Status: VALIDATED

Source sequence(s)

AC174452

UniProtKB/Swiss-Prot

Q9ERQ9

Related

ENSMUSP00000101148.2, ENSMUST00000105509.2

Conserved Domains (2) summary

cd22071
Location:485 → 559

WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)

NF033761
Location:394 → 498

gliding_GltJ; adventurous gliding motility protein GltJ
NM_001379454.1 → NP_001366383.1 actin-binding protein WASF1 isoform 2

Status: VALIDATED

Source sequence(s)

AC174452

Conserved Domains (2) summary

cd22071
Location:484 → 558

WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)

NF033761
Location:393 → 497

gliding_GltJ; adventurous gliding motility protein GltJ
NM_031877.3 → NP_114083.1 actin-binding protein WASF1 isoform 1

See identical proteins and their annotated locations for NP_114083.1

Status: VALIDATED

Source sequence(s)

AF290877, BC053423, BY332208

Consensus CDS

CCDS23801.1

UniProtKB/Swiss-Prot

Q8R5H6, Q9ERQ9

Related

ENSMUSP00000019975.8, ENSMUST00000019975.14

Conserved Domains (2) summary

cd22071
Location:485 → 559

WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)

NF033761
Location:394 → 498

gliding_GltJ; adventurous gliding motility protein GltJ

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

40759476..40814565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245406.1 → XP_030101266.1 wiskott-Aldrich syndrome protein family member 1 isoform X1

Conserved Domains (2) summary

cd22071
Location:484 → 558

WH2_WAVE-1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1)

NF033761
Location:393 → 497

gliding_GltJ; adventurous gliding motility protein GltJ