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RBP5 retinol binding protein 5 [ Homo sapiens (human) ]

Gene ID: 83758, updated on 25-Nov-2021

Summary

Official Symbol
RBP5provided by HGNC
Official Full Name
retinol binding protein 5provided by HGNC
Primary source
HGNC:HGNC:15847
See related
Ensembl:ENSG00000139194 MIM:611866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRBP3; CRBPIII; HRBPiso; CRBP-III
Summary
The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]
Expression
Biased expression in kidney (RPKM 131.3), liver (RPKM 58.1) and 3 other tissues See more
Orthologs
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Genomic context

See RBP5 in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (7119106..7130272, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7276282..7282601, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene complement C1r subcomponent like Neighboring gene C1RL antisense RNA 1 Neighboring gene RNA, U6 small nuclear 485, pseudogene Neighboring gene calsyntenin 3 Neighboring gene peroxisomal biogenesis factor 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
 
enables retinoid binding TAS
Traceable Author Statement
more info
PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
retinol-binding protein 5
Names
cellular retinol-binding protein III
putative cellular retinol-binding protein CRBP III
retinol binding protein 5, cellular

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329454.2NP_001316383.1  retinol-binding protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC018653, AC233309
  2. NM_031491.4NP_113679.1  retinol-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_113679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA912830, BC029355
    Consensus CDS
    CCDS8574.1
    UniProtKB/Swiss-Prot
    P82980
    Related
    ENSP00000266560.3, ENST00000266560.8
    Conserved Domains (1) summary
    pfam00061
    Location:6105
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    7119106..7130272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020002.1XP_016875491.1  retinol-binding protein 5 isoform X1

    Conserved Domains (1) summary
    pfam00061
    Location:1492
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. XR_001748882.1 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160008.1 Reference GRCh38.p13 PATCHES

    Range
    51372..57691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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