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TAS1R3 taste 1 receptor member 3 [ Homo sapiens (human) ]

Gene ID: 83756, updated on 1-Jun-2020

Summary

Official Symbol
TAS1R3provided by HGNC
Official Full Name
taste 1 receptor member 3provided by HGNC
Primary source
HGNC:HGNC:15661
See related
Ensembl:ENSG00000169962 MIM:605865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1R3
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
Expression
Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues See more
Orthologs

Genomic context

See TAS1R3 in Genome Data Viewer
Location:
1p36.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1331280..1335320)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1266726..1269844)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 11 Neighboring gene microRNA 6727 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808 Neighboring gene matrix remodeling associated 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to sweet taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
taste receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sweet taste receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
taste receptor type 1 member 3
Names
sweet taste receptor T1R3
taste receptor, type 1, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152228.3NP_689414.2  taste receptor type 1 member 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL139287
    Consensus CDS
    CCDS30556.1
    Related
    ENSP00000344411.5, ENST00000339381.6
    Conserved Domains (3) summary
    cd06363
    Location:29488
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam07562
    Location:496547
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15290
    Location:590819
    7tmC_TAS1R3; type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1331280..1335320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002435.1XP_016857924.1  taste receptor type 1 member 3 isoform X1

  2. XM_017002436.1XP_016857925.1  taste receptor type 1 member 3 isoform X2

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