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AAP8 amino acid permease 8 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837536, updated on 18-Sep-2024

Summary

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Official Symbol
AAP8
Official Full Name
amino acid permease 8
Primary source
TAIR:AT1G10010
Locus tag
AT1G10010
See related
Araport:AT1G10010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
amino acid permease 8; ATAAP8; T27I1.3; T27I1_3
Summary
Encodes a high affinity amino acid transporter that is probably responsible for import of organic nitrogen into developing seeds. One of eight gene family members that encode amino acid permeases. Most closely related to AAP1 (75%) identity.
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Genomic context

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See AAP8 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Sequence:
Chromosome: 1; NC_003070.9 (3265886..3268823)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DNA repair DEAD helicase RAD3/XP-D subfamily protein Neighboring gene Ribonuclease H-like superfamily protein Neighboring gene formin-like protein (DUF1005) Neighboring gene ergosterol biosynthesis protein Neighboring gene alpha/beta-Hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Connecting Source with Sink: The Role of Arabidopsis AAP8 in Phloem Loading of Amino Acids. Santiago JP, et al. Plant Physiol, 2016 May. PMID 27016446, Free PMC Article
  2. The amino acid permease AAP8 is important for early seed development in Arabidopsis thaliana. Schmidt R, et al. Planta, 2007 Sep. PMID 17476526
  3. High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis. Okumoto S, et al. J Biol Chem, 2002 Nov 22. PMID 12244056
  4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AAP8 is important for the import of neutral and acidic amino acids into the phloem, but does not play a role in seed nitrogen filling.
    Title: Connecting Source with Sink: The Role of Arabidopsis AAP8 in Phloem Loading of Amino Acids.
  2. crucial role for the uptake of amino acids into the endosperm and supplying the developing embryo with amino acids during early embryogenesis
    Title: The amino acid permease AAP8 is important for early seed development in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
amino acid permease 8
NP_172472.1
  • amino acid permease 8 (AAP8); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: amino acid permease 1 (TAIR:AT1G58360.1); Has 2959 Blast hits to 2943 proteins in 246 species: Archae - 0; Bacteria - 24; Metazoa - 771; Fungi - 529; Plants - 1378; Viruses - 0; Other Eukaryotes - 257 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3265886..3268823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331877.1 → NP_001322343.1  amino acid permease 8 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ATS1, A0A5S9TKZ7

  2. NM_100875.1 → NP_172472.1  amino acid permease 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172472.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80592
    UniProtKB/TrEMBL
    A0A5S9TKZ7
    Conserved Domains (2) summary
    COG0814
    Location:39 → 462
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam01490
    Location:28 → 462
    Aa_trans; Transmembrane amino acid transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80592.1

Gene LinkOut

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