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ATG10 autophagy related 10 [ Homo sapiens (human) ]

Gene ID: 83734, updated on 21-Jun-2020

Summary

Official Symbol
ATG10provided by HGNC
Official Full Name
autophagy related 10provided by HGNC
Primary source
HGNC:HGNC:20315
See related
Ensembl:ENSG00000152348 MIM:610800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APG10; APG10L; pp12616
Summary
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 1.1), thyroid (RPKM 0.8) and 25 other tissues See more
Orthologs

Genomic context

See ATG10 in Genome Data Viewer
Location:
5q14.1-q14.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (81972021..82258502)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (81267844..81551958)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986385 Neighboring gene SEM1 pseudogene 1 Neighboring gene VISTA enhancer hs1432 Neighboring gene peptidylprolyl isomerase A pseudogene 11 Neighboring gene RNA, 7SL, cytoplasmic 378, pseudogene Neighboring gene ATPase H+ transporting accessory protein 1 like Neighboring gene ribosomal protein S23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13954, DKFZp586I0418

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Atg12 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Atg12 transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
ER overload response IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
positive regulation of protein modification process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein lipidation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein modification by small protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquitin-like-conjugating enzyme ATG10
Names
APG10 autophagy 10-like
ATG10 autophagy related 10 homolog
autophagy-related protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131028.2NP_001124500.1  ubiquitin-like-conjugating enzyme ATG10

    See identical proteins and their annotated locations for NP_001124500.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010598, AC114969, AI436652, AK225969, AL136912
    Consensus CDS
    CCDS4057.1
    UniProtKB/Swiss-Prot
    Q9H0Y0
    Related
    ENSP00000404938.3, ENST00000458350.7
    Conserved Domains (1) summary
    pfam03987
    Location:100167
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
  2. NM_031482.5NP_113670.1  ubiquitin-like-conjugating enzyme ATG10

    See identical proteins and their annotated locations for NP_113670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC010598, AC114969, AI436652, AK225969, BC029268
    Consensus CDS
    CCDS4057.1
    UniProtKB/Swiss-Prot
    Q9H0Y0
    Related
    ENSP00000282185.3, ENST00000282185.8
    Conserved Domains (1) summary
    pfam03987
    Location:100167
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    81972021..82258502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009944.1XP_016865433.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

    Conserved Domains (1) summary
    pfam03987
    Location:64131
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
  2. XM_005248612.3XP_005248669.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

    Conserved Domains (1) summary
    pfam03987
    Location:64131
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
  3. XM_005248611.5XP_005248668.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

    See identical proteins and their annotated locations for XP_005248668.1

    UniProtKB/Swiss-Prot
    Q9H0Y0
    Related
    ENSP00000425225.1, ENST00000513634.1
    Conserved Domains (1) summary
    pfam03987
    Location:100167
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
  4. XM_005248610.5XP_005248667.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

    See identical proteins and their annotated locations for XP_005248667.1

    UniProtKB/Swiss-Prot
    Q9H0Y0
    Conserved Domains (1) summary
    pfam03987
    Location:100167
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
  5. XM_011543660.2XP_011541962.1  ubiquitin-like-conjugating enzyme ATG10 isoform X3

    Conserved Domains (1) summary
    pfam03987
    Location:58125
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
  6. XM_011543661.2XP_011541963.1  ubiquitin-like-conjugating enzyme ATG10 isoform X4

    Conserved Domains (1) summary
    pfam03987
    Location:3097
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
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