Format

Send to:

Choose Destination

LIG1 DNA ligase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837333, updated on 14-Feb-2017
Gene symbol
LIG1
Gene description
DNA ligase 1
Primary source
Araport:AT1G08130
Locus tag
AT1G08130
Gene type
protein coding
RNA name
DNA ligase 1
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATLIG1; DNA ligase 1; T6D22.23
Summary
Encodes the Arabidopsis DNA ligase 1 that provides the major DNA ligase activity in cells and plays a key role in both DNA replication and excision repair pathways. Indispensable for cell viability. AtLIG1 expresses one major and two minor mRNA transcripts differing only in the length of the 5' untranslated leader sequences preceding a common ORF. Translation from the first in-frame start codon produces an AtLIG1 isoform that is targeted exclusively to the mitochondria. Translation initiation from the second in-frame start codon produces an AtLIG1 isoform targeted only to the nucleus.
See LIG1 in Map Viewer
Location:
chromosome: 1
Exon count:
17
Sequence:
Chromosome: 1; NC_003070.9 (2542663..2547946, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TP53-regulating kinase-like protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene cation/H+ exchanger 6B Neighboring gene cation/H+ exchanger 6A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

NM_100689.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA ligase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA ligase (ATP) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA ligation involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
single strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISM
Inferred from Sequence Model
more info
 
Names
DNA ligase 1
NP_172293.2
  • DNA ligase 1 (LIG1); FUNCTIONS IN: DNA binding, DNA ligase (ATP) activity, ATP binding; INVOLVED IN: DNA repair, DNA replication, DNA recombination; LOCATED IN: mitochondrion, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA ligase, N-terminal (InterPro:IPR012308), ATP dependent DNA ligase, central (InterPro:IPR012310), ATP dependent DNA ligase, C-terminal (InterPro:IPR012309), ATP-dependent DNA ligase (InterPro:IPR000977), ATP-dependent DNA ligase, conserved site (InterPro:IPR016059); BEST Arabidopsis thaliana protein match is: ATP-dependent DNA ligase (TAIR:AT1G49250.1); Has 3556 Blast hits to 3521 proteins in 879 species: Archae - 298; Bacteria - 1538; Metazoa - 375; Fungi - 434; Plants - 112; Viruses - 159; Other Eukaryotes - 640 (source: NCBI BLink).

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2542663..2547946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100689.5NP_172293.2  DNA ligase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172293.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42572
    Conserved Domains (4) summary
    cd07969
    Location:630775
    OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
    cd07900
    Location:407625
    Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I
    PLN03113
    Location:49790
    PLN03113; DNA ligase 1; Provisional
    pfam04675
    Location:176347
    DNA_ligase_A_N; DNA ligase N terminus
Support Center