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SLC25A18 solute carrier family 25 member 18 [ Homo sapiens (human) ]

Gene ID: 83733, updated on 23-Nov-2021

Summary

Official Symbol
SLC25A18provided by HGNC
Official Full Name
solute carrier family 25 member 18provided by HGNC
Primary source
HGNC:HGNC:10988
See related
Ensembl:ENSG00000182902 MIM:609303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GC2
Expression
Biased expression in brain (RPKM 15.7), liver (RPKM 8.1) and 2 other tissues See more
Orthologs
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Genomic context

See SLC25A18 in Genome Data Viewer
Location:
22q11.21
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (17562470..17592256)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18043198..18073761)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene CECR2 histone acetyl-lysine reader Neighboring gene Charcot-Leyden crystal protein pseudogene 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 6 Neighboring gene uncharacterized LOC105372850 Neighboring gene uncharacterized LOC101929372 Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene BCL2 like 13 Neighboring gene microRNA 3198-1 Neighboring gene BH3 interacting domain death agonist

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amino acid:proton symporter activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mitochondrial glutamate carrier 2
Names
glutamate/H(+) symporter 2
solute carrier family 25 (glutamate carrier), member 18
solute carrier family 25 (mitochondrial carrier), member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303484.2NP_001290413.1  mitochondrial glutamate carrier 2

    See identical proteins and their annotated locations for NP_001290413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007666, BC031644, HY351290
    Consensus CDS
    CCDS13744.1
    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Related
    ENSP00000382710.1, ENST00000399813.1
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein
  2. NM_031481.3NP_113669.1  mitochondrial glutamate carrier 2

    See identical proteins and their annotated locations for NP_113669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007666, AY008285, HY351290
    Consensus CDS
    CCDS13744.1
    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Related
    ENSP00000329033.5, ENST00000327451.11
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    17562470..17592256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546150.2XP_011544452.1  mitochondrial glutamate carrier 2 isoform X2

    Conserved Domains (2) summary
    PTZ00168
    Location:63356
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:55148
    Mito_carr; Mitochondrial carrier protein
  2. XM_011546149.2XP_011544451.1  mitochondrial glutamate carrier 2 isoform X1

    Conserved Domains (2) summary
    PTZ00168
    Location:107400
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:99192
    Mito_carr; Mitochondrial carrier protein
  3. XM_017028975.2XP_016884464.1  mitochondrial glutamate carrier 2 isoform X4

  4. XM_017028971.2XP_016884460.1  mitochondrial glutamate carrier 2 isoform X4

  5. XM_011546153.3XP_011544455.1  mitochondrial glutamate carrier 2 isoform X3

    See identical proteins and their annotated locations for XP_011544455.1

    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein
  6. XM_017028970.2XP_016884459.1  mitochondrial glutamate carrier 2 isoform X4

  7. XM_017028972.2XP_016884461.1  mitochondrial glutamate carrier 2 isoform X4

  8. XM_017028974.2XP_016884463.1  mitochondrial glutamate carrier 2 isoform X4

  9. XM_017028973.2XP_016884462.1  mitochondrial glutamate carrier 2 isoform X4

  10. XM_011546154.2XP_011544456.1  mitochondrial glutamate carrier 2 isoform X3

    See identical proteins and their annotated locations for XP_011544456.1

    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein
  11. XM_011546151.2XP_011544453.1  mitochondrial glutamate carrier 2 isoform X3

    See identical proteins and their annotated locations for XP_011544453.1

    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein
  12. XM_011546152.1XP_011544454.1  mitochondrial glutamate carrier 2 isoform X3

    See identical proteins and their annotated locations for XP_011544454.1

    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein
  13. XM_017028968.1XP_016884457.1  mitochondrial glutamate carrier 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H1K4
    UniProtKB/TrEMBL
    A0A024R0W0
    Conserved Domains (1) summary
    pfam00153
    Location:497
    Mito_carr; Mitochondrial carrier protein

RNA

  1. XR_951210.3 RNA Sequence

  2. XR_002958717.1 RNA Sequence

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