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Clic4 chloride intracellular channel 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83718, updated on 13-Apr-2024

Summary

Official Symbol
Clic4provided by RGD
Official Full Name
chloride intracellular channel 4provided by RGD
Primary source
RGD:61857
See related
Ensembl:ENSRNOG00000018109 AllianceGenome:RGD:61857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chloride channel activity. Predicted to be involved in several processes, including cellular response to calcium ion; chloride transport; and keratinocyte differentiation. Predicted to act upstream of or within several processes, including endothelial cell morphogenesis; vacuolar acidification; and vasculature development. Predicted to be located in several cellular components, including centrosome; midbody; and nuclear matrix. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Predicted to colocalize with microtubule cytoskeleton. Orthologous to human CLIC4 (chloride intracellular channel 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1064.7), Kidney (RPKM 906.2) and 9 other tissues See more
Orthologs
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Genomic context

See Clic4 in Genome Data Viewer
Location:
5q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (152737371..152797118, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147453702..147513455, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (153568937..153625669, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RUNX family transcription factor 3 Neighboring gene uncharacterized LOC134487009 Neighboring gene uncharacterized LOC134479039 Neighboring gene uncharacterized LOC120103007 Neighboring gene serine and arginine repetitive matrix 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transport TAS
Traceable Author Statement
more info
PubMed 
involved_in endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endothelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in fertilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in retina vasculature morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in vacuolar acidification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vacuolar acidification ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
chloride intracellular channel protein 4
Names
chloride intracellular channel 4 (mitochondrial)
intracellular chloride ion channel protein p64H1
mitochondrial chloride intracellular channel 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031818.2NP_114006.2  chloride intracellular channel protein 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IT49, G3V8C4
    Related
    ENSRNOP00000024464.1, ENSRNOT00000024464.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    152737371..152797118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)