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PDS1 4-hydroxyphenylpyruvate dioxygenase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837168, updated on 19-Feb-2025
Official Symbol
PDS1
Official Full Name
4-hydroxyphenylpyruvate dioxygenase
Primary source
TAIR:AT1G06570
Locus tag
AT1G06570
See related
Araport:AT1G06570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
4-hydroxyphenylpyruvate dioxygenase; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; F12K11.9; F12K11_9; HPD; HPPD; P-HYDROXYPHENYLPYRUVATE DIOXYGENASE; phytoene desaturation 1
Summary
Mutation of the PDS1 locus disrupts the activity of p-hydroxyphenylpyruvate dioxygenase (HPPDase), the first committed step in the synthesis of both plastoquinone and tocopherols in plants.
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See PDS1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (2011885..2013545, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ATP-dependent caseinolytic (Clp) protease/crotonase family protein Neighboring gene NOL1/NOP2/sun family protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene anaphase-promoting complex subunit

Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Fritze IM, et al. Plant Physiol, 2004 Apr. PMID 15084729, Free PMC Article
  2. Characterization and subcellular compartmentation of recombinant 4-hydroxyphenylpyruvate dioxygenase from Arabidopsis in transgenic tobacco. Garcia I, et al. Plant Physiol, 1999 Apr. PMID 10198110, Free PMC Article
  3. Complementation of the Arabidopsis pds1 mutation with the gene encoding p-hydroxyphenylpyruvate dioxygenase. Norris SR, et al. Plant Physiol, 1998 Aug. PMID 9701587, Free PMC Article
  4. Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases. Yang C, et al. Biochemistry, 2004 Aug 17. PMID 15301540
  5. Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation. Norris SR, et al. Plant Cell, 1995 Dec. PMID 8718624, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

NM_001160839.1
NM_100536.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-hydroxyphenylpyruvate dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carotenoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plastoquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vitamin E biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in mitochondrion HDA PubMed 
Preferred Names
4-hydroxyphenylpyruvate dioxygenase
NP_001154311.1
  • phytoene desaturation 1 (PDS1); CONTAINS InterPro DOMAIN/s: 4-hydroxyphenylpyruvate dioxygenase (InterPro:IPR005956), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); Has 2393 Blast hits to 2392 proteins in 824 species: Archae - 3; Bacteria - 1672; Metazoa - 205; Fungi - 157; Plants - 91; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).
NP_172144.3
  • phytoene desaturation 1 (PDS1); CONTAINS InterPro DOMAIN/s: 4-hydroxyphenylpyruvate dioxygenase (InterPro:IPR005956), Glyoxalase/bleomycin resistance protein/dioxygenase (InterPro:IPR004360); Has 2414 Blast hits to 2412 proteins in 817 species: Archae - 3; Bacteria - 1671; Metazoa - 206; Fungi - 158; Plants - 88; Viruses - 0; Other Eukaryotes - 288 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2011885..2013545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160839.1 → NP_001154311.1  4-hydroxyphenylpyruvate dioxygenase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WHQ7, F4IDP2
    Conserved Domains (3) summary
    cd07250
    Location:249 → 416
    HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
    cd08342
    Location:75 → 235
    HPPD_N_like; N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
    PLN02875
    Location:75 → 416
    PLN02875; 4-hydroxyphenylpyruvate dioxygenase

  2. NM_100536.4 → NP_172144.3  4-hydroxyphenylpyruvate dioxygenase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IDP1, O04330, P93836, Q9SHK1
    UniProtKB/TrEMBL
    A0A178WHQ7, A0A5S9SZ06, A0A654E7B4
    Conserved Domains (1) summary
    PLN02875
    Location:47 → 440
    PLN02875; 4-hydroxyphenylpyruvate dioxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P93836.2

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