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GSK1 GSK3/SHAGGY-like protein kinase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837150, updated on 27-Sep-2019

Summary

Gene symbol
GSK1
Gene description
GSK3/SHAGGY-like protein kinase 1
Primary source
Araport:AT1G06390
Locus tag
AT1G06390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
A. THALIANA SHAGGY-LIKE KINASE GROUP 2 3; ATGSK1; ATSK2-3; ATSK22; BIL2; BIN2-LIKE 2; GSK3/SHAGGY-LIKE PROTEIN KINASE; GSK3/SHAGGY-like protein kinase 1; SHAGGY-LIKE PROTEIN KINASE 22; SK22; T2D23.9; T2D23_9
Summary
encodes a GSK3/shaggy-like protein kinase. Gene expression is induced by NaCl and ABA but not KCl, suggesting that this gene may be involved in response to osmotic stress. This protein can interact with the BZR1 protein involved in brassinosteroid-mediated signaling in a Y2H assay and promotes BZR1 phosphorylation in protoplasts.

Genomic context

See GSK1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (1946746..1950860)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Ribosomal protein L1p/L10e family Neighboring gene Ras-related small GTP-binding family protein Neighboring gene ncRNA Neighboring gene trehalose-phosphatase/synthase 7

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

NM_100519.3
NM_202042.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
brassinosteroid mediated signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GSK3/SHAGGY-like protein kinase 1
NP_172127.1
  • GSK3/SHAGGY-like protein kinase 1 (GSK1); FUNCTIONS IN: kinase activity, glycogen synthase kinase 3 activity; INVOLVED IN: brassinosteroid mediated signaling pathway, protein amino acid phosphorylation, hyperosmotic salinity response, regulation of protein localization; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: SHAGGY-related protein kinase dZeta (TAIR:AT2G30980.1); Has 107835 Blast hits to 106562 proteins in 3623 species: Archae - 81; Bacteria - 10704; Metazoa - 38361; Fungi - 11903; Plants - 28114; Viruses - 380; Other Eukaryotes - 18292 (source: NCBI BLink).
NP_973771.1
  • GSK3/SHAGGY-like protein kinase 1 (GSK1); FUNCTIONS IN: kinase activity, glycogen synthase kinase 3 activity; INVOLVED IN: brassinosteroid mediated signaling pathway, protein amino acid phosphorylation, hyperosmotic salinity response, regulation of protein localization; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: SHAGGY-related protein kinase dZeta (TAIR:AT2G30980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1946746..1950860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100519.3NP_172127.1  GSK3/SHAGGY-like protein kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172127.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39012
    UniProtKB/TrEMBL
    A0A178WCN5
    Conserved Domains (2) summary
    smart00220
    Location:70354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:65357
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
  2. NM_202042.3NP_973771.1  GSK3/SHAGGY-like protein kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39012
    UniProtKB/TrEMBL
    A0A178WCN5
    Conserved Domains (2) summary
    smart00220
    Location:70354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:65357
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
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