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TRPT1 tRNA phosphotransferase 1 [ Homo sapiens (human) ]

Gene ID: 83707, updated on 17-Jun-2024

Summary

Official Symbol
TRPT1provided by HGNC
Official Full Name
tRNA phosphotransferase 1provided by HGNC
Primary source
HGNC:HGNC:20316
See related
Ensembl:ENSG00000149743 MIM:610470; AllianceGenome:HGNC:20316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 18.8), duodenum (RPKM 15.3) and 25 other tissues See more
Orthologs
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Genomic context

See TRPT1 in Genome Data Viewer
Location:
11q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64223799..64226257, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64213745..64216203, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63991271..63993658, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3460 Neighboring gene uncharacterized LOC105369339 Neighboring gene MPRA-validated peak1294 silencer Neighboring gene uncharacterized LOC124902686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63948751-63949252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63949253-63949752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63951637-63952142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3462 Neighboring gene stress induced phosphoprotein 1 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:63972802-63973364 and GRCh37_chr11:63973365-63973927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4888 Neighboring gene FERM domain containing kindlin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63992564-63993286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene uncharacterized LOC124902687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene nudix hydrolase 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of the child behavior checklist dysregulation profile.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tRNA phosphotransferase 1 (TRPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
tRNA 2'-phosphotransferase 1
Names
tRNA splicing 2' phosphotransferase 1
NP_001028850.2
NP_001153861.1
NP_001153862.1
NP_001153864.1
NP_001153865.1
NP_001317227.1
NP_113660.1
XP_005274402.1
XP_005274403.1
XP_005274404.1
XP_006718770.1
XP_016873889.1
XP_024304476.1
XP_024304477.1
XP_047283635.1
XP_047283636.1
XP_047283637.1
XP_047283638.1
XP_054226108.1
XP_054226109.1
XP_054226110.1
XP_054226111.1
XP_054226112.1
XP_054226113.1
XP_054226114.1
XP_054226115.1
XP_054226116.1
XP_054226117.1
XP_054226118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033678.4NP_001028850.2  tRNA 2'-phosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001028850.2

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS31595.1
    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Related
    ENSP00000314073.6, ENST00000317459.11
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  2. NM_001160389.2NP_001153861.1  tRNA 2'-phosphotransferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS53652.1
    UniProtKB/Swiss-Prot
    Q86TN4
    Related
    ENSP00000378050.2, ENST00000394546.6
    Conserved Domains (1) summary
    pfam01885
    Location:31204
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  3. NM_001160390.2NP_001153862.1  tRNA 2'-phosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001153862.1

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS31595.1
    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  4. NM_001160392.2NP_001153864.1  tRNA 2'-phosphotransferase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS53653.1
    UniProtKB/TrEMBL
    F5H8A0
    Related
    ENSP00000438683.1, ENST00000541278.5
    Conserved Domains (1) summary
    pfam01885
    Location:31186
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  5. NM_001160393.1NP_001153865.1  tRNA 2'-phosphotransferase 1 isoform 5

    See identical proteins and their annotated locations for NP_001153865.1

    Status: VALIDATED

    Source sequence(s)
    AY211494, BC005133, BM982538
    UniProtKB/Swiss-Prot
    Q86TN4
    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  6. NM_001330298.2NP_001317227.1  tRNA 2'-phosphotransferase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS81579.1
    UniProtKB/TrEMBL
    F5H6B6
    Related
    ENSP00000437741.1, ENST00000546089.5
  7. NM_031472.4NP_113660.1  tRNA 2'-phosphotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_113660.1

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS44639.1
    Related
    ENSP00000378051.3, ENST00000394547.7
    Conserved Domains (1) summary
    pfam01885
    Location:1154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64223799..64226257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448709.2XP_024304477.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  2. XM_047427679.1XP_047283635.1  tRNA 2'-phosphotransferase 1 isoform X3

    UniProtKB/TrEMBL
    F5H8A0
  3. XM_006718707.4XP_006718770.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006718770.1

    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  4. XM_024448708.2XP_024304476.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  5. XM_005274346.5XP_005274403.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005274403.1

    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  6. XM_047427682.1XP_047283638.1  tRNA 2'-phosphotransferase 1 isoform X6

    UniProtKB/TrEMBL
    F5H1K3
    Related
    ENSP00000439586.1, ENST00000546133.5
  7. XM_047427681.1XP_047283637.1  tRNA 2'-phosphotransferase 1 isoform X5

  8. XM_017018400.2XP_016873889.1  tRNA 2'-phosphotransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam01885
    Location:1154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  9. XM_047427680.1XP_047283636.1  tRNA 2'-phosphotransferase 1 isoform X3

    UniProtKB/TrEMBL
    F5H8A0
  10. XM_005274347.5XP_005274404.1  tRNA 2'-phosphotransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam01885
    Location:1154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  11. XM_005274345.5XP_005274402.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005274402.1

    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64213745..64216203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370136.1XP_054226111.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
  2. XM_054370137.1XP_054226112.1  tRNA 2'-phosphotransferase 1 isoform X3

    UniProtKB/TrEMBL
    F5H8A0
  3. XM_054370135.1XP_054226110.1  tRNA 2'-phosphotransferase 1 isoform X1

  4. XM_054370143.1XP_054226118.1  tRNA 2'-phosphotransferase 1 isoform X6

    UniProtKB/TrEMBL
    F5H1K3
  5. XM_054370142.1XP_054226117.1  tRNA 2'-phosphotransferase 1 isoform X5

  6. XM_054370141.1XP_054226116.1  tRNA 2'-phosphotransferase 1 isoform X4

  7. XM_054370139.1XP_054226114.1  tRNA 2'-phosphotransferase 1 isoform X3

    UniProtKB/TrEMBL
    F5H8A0
  8. XM_054370140.1XP_054226115.1  tRNA 2'-phosphotransferase 1 isoform X4

  9. XM_054370138.1XP_054226113.1  tRNA 2'-phosphotransferase 1 isoform X1

  10. XM_054370134.1XP_054226109.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
  11. XM_054370133.1XP_054226108.1  tRNA 2'-phosphotransferase 1 isoform X1