U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TRPT1 tRNA phosphotransferase 1 [ Homo sapiens (human) ]

Gene ID: 83707, updated on 12-Aug-2022

Summary

Official Symbol
TRPT1provided by HGNC
Official Full Name
tRNA phosphotransferase 1provided by HGNC
Primary source
HGNC:HGNC:20316
See related
Ensembl:ENSG00000149743 MIM:610470; AllianceGenome:HGNC:20316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 18.8), duodenum (RPKM 15.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TRPT1 in Genome Data Viewer
Location:
11q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64223799..64226257, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64213745..64216132, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63991271..63993658, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369339 Neighboring gene uncharacterized LOC124902686 Neighboring gene stress induced phosphoprotein 1 Neighboring gene FERM domain containing kindlin 3 Neighboring gene uncharacterized LOC124902687 Neighboring gene nudix hydrolase 22 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of the child behavior checklist dysregulation profile.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tRNA phosphotransferase 1 (TRPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables tRNA 2'-phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA 2'-phosphotransferase 1
Names
tRNA splicing 2' phosphotransferase 1
NP_001028850.2
NP_001153861.1
NP_001153862.1
NP_001153864.1
NP_001153865.1
NP_001317227.1
NP_113660.1
XP_005274402.1
XP_005274403.1
XP_005274404.1
XP_006718770.1
XP_016873889.1
XP_024304476.1
XP_024304477.1
XP_047283635.1
XP_047283636.1
XP_047283637.1
XP_047283638.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033678.4NP_001028850.2  tRNA 2'-phosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001028850.2

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS31595.1
    UniProtKB/Swiss-Prot
    Q86TN4, Q9BSB9
    Related
    ENSP00000314073.6, ENST00000317459.11
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  2. NM_001160389.2NP_001153861.1  tRNA 2'-phosphotransferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS53652.1
    UniProtKB/Swiss-Prot
    Q86TN4
    Related
    ENSP00000378050.2, ENST00000394546.6
    Conserved Domains (1) summary
    pfam01885
    Location:31204
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  3. NM_001160390.2NP_001153862.1  tRNA 2'-phosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001153862.1

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS31595.1
    UniProtKB/Swiss-Prot
    Q86TN4, Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  4. NM_001160392.2NP_001153864.1  tRNA 2'-phosphotransferase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS53653.1
    UniProtKB/Swiss-Prot
    Q86TN4
    Related
    ENSP00000438683.1, ENST00000541278.5
    Conserved Domains (1) summary
    pfam01885
    Location:31186
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  5. NM_001160393.1NP_001153865.1  tRNA 2'-phosphotransferase 1 isoform 5

    See identical proteins and their annotated locations for NP_001153865.1

    Status: VALIDATED

    Source sequence(s)
    AY211494, BC005133, BM982538
    UniProtKB/Swiss-Prot
    Q86TN4
    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  6. NM_001330298.2NP_001317227.1  tRNA 2'-phosphotransferase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS81579.1
    UniProtKB/Swiss-Prot
    Q86TN4
    UniProtKB/TrEMBL
    F5H6B6
    Related
    ENSP00000437741.1, ENST00000546089.5
  7. NM_031472.4NP_113660.1  tRNA 2'-phosphotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_113660.1

    Status: VALIDATED

    Source sequence(s)
    AP005668, AP006334
    Consensus CDS
    CCDS44639.1
    UniProtKB/Swiss-Prot
    Q86TN4
    UniProtKB/TrEMBL
    A0A024R5C2
    Related
    ENSP00000378051.3, ENST00000394547.7
    Conserved Domains (1) summary
    pfam01885
    Location:1154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64223799..64226257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448709.2XP_024304477.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  2. XM_047427679.1XP_047283635.1  tRNA 2'-phosphotransferase 1 isoform X3

  3. XM_006718707.4XP_006718770.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006718770.1

    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  4. XM_024448708.2XP_024304476.1  tRNA 2'-phosphotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9BSB9
    Conserved Domains (1) summary
    pfam01885
    Location:26203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  5. XM_005274346.5XP_005274403.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005274403.1

    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  6. XM_047427682.1XP_047283638.1  tRNA 2'-phosphotransferase 1 isoform X6

    Related
    ENSP00000439586.1, ENST00000546133.5
  7. XM_047427681.1XP_047283637.1  tRNA 2'-phosphotransferase 1 isoform X5

    UniProtKB/TrEMBL
    A0A024R5C2
  8. XM_017018400.2XP_016873889.1  tRNA 2'-phosphotransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam01885
    Location:1154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  9. XM_047427680.1XP_047283636.1  tRNA 2'-phosphotransferase 1 isoform X3

  10. XM_005274347.5XP_005274404.1  tRNA 2'-phosphotransferase 1 isoform X4

    Conserved Domains (1) summary
    pfam01885
    Location:1154
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
  11. XM_005274345.5XP_005274402.1  tRNA 2'-phosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005274402.1

    Conserved Domains (1) summary
    pfam01885
    Location:31203
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64213745..64216132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)