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Dbr1 debranching RNA lariats 1 [ Mus musculus (house mouse) ]

Gene ID: 83703, updated on 25-May-2024

Summary

Official Symbol
Dbr1provided by MGI
Official Full Name
debranching RNA lariats 1provided by MGI
Primary source
MGI:MGI:1931520
See related
Ensembl:ENSMUSG00000032469 AllianceGenome:MGI:1931520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA lariat debranching enzyme activity. Acts upstream of or within mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and skin. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.4), liver E14 (RPKM 7.1) and 28 other tissues See more
Orthologs
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Genomic context

See Dbr1 in Genome Data Viewer
Location:
9 E3.3; 9 51.86 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99457839..99467060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99575786..99585007)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene NME/NM23 family member 9 Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene armadillo repeat containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6796 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene DAZ interacting protein 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA lariat debranching enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA lariat debranching enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA lariat debranching enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA fragment catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA splicing, via transesterification reactions ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lariat debranching enzyme
Names
debranching enzyme homolog 1
NP_001355227.1
NP_113580.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368298.1NP_001355227.1  lariat debranching enzyme isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156497
  2. NM_031403.3NP_113580.2  lariat debranching enzyme isoform 1

    See identical proteins and their annotated locations for NP_113580.2

    Status: VALIDATED

    Source sequence(s)
    AK050090
    Consensus CDS
    CCDS23435.1
    UniProtKB/Swiss-Prot
    Q8C1T9, Q8C7J7, Q923B1, Q99MT1
    Related
    ENSMUSP00000070991.6, ENSMUST00000066650.12
    Conserved Domains (3) summary
    cd00844
    Location:3264
    MPP_Dbr1_N; Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain
    pfam00149
    Location:1229
    Metallophos; Calcineurin-like phosphoesterase
    pfam05011
    Location:246377
    DBR1; Lariat debranching enzyme, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99457839..99467060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)