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Srrt serrate RNA effector molecule homolog (Arabidopsis) [ Mus musculus (house mouse) ]

Gene ID: 83701, updated on 12-May-2024

Summary

Official Symbol
Srrtprovided by MGI
Official Full Name
serrate RNA effector molecule homolog (Arabidopsis)provided by MGI
Primary source
MGI:MGI:1933527
See related
Ensembl:ENSMUSG00000037364 AllianceGenome:MGI:1933527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ars2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; 2810019G02Rik
Summary
Enables DNA binding activity. Involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; liver; lung; retina; and spleen. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 42.3), thymus adult (RPKM 37.8) and 28 other tissues See more
Orthologs
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Genomic context

See Srrt in Genome Data Viewer
Location:
5 G2; 5 76.33 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137293966..137306564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137295704..137307716, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetylcholinesterase Neighboring gene microRNA 8116 Neighboring gene UFM1-specific peptidase 1 Neighboring gene microRNA 7036 Neighboring gene STARR-seq mESC enhancer starr_14639 Neighboring gene predicted gene 43013 Neighboring gene thyroid hormone receptor interactor 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA cap binding complex binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serrate RNA effector molecule homolog
Names
arsenate resistance protein 2
arsenite-resistance protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109909.1NP_001103379.1  serrate RNA effector molecule homolog isoform 2

    See identical proteins and their annotated locations for NP_001103379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different acceptor splice site at the penultimate exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 7 aa segment, compared to isoform 1.
    Source sequence(s)
    AA986426, BC066831, CJ175065
    Consensus CDS
    CCDS80440.1
    UniProtKB/Swiss-Prot
    Q99MR6
    Related
    ENSMUSP00000143232.2, ENSMUST00000199243.5
    Conserved Domains (2) summary
    pfam04959
    Location:645843
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)
  2. NM_001109910.1NP_001103380.1  serrate RNA effector molecule homolog isoform 3

    See identical proteins and their annotated locations for NP_001103380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses different acceptor splice sites at the second and third to last exons compared to transcript variant 1, resulting in a shorter isoform (3) compared to isoform 1.
    Source sequence(s)
    AA986426, AK152710, BC066831, CJ175065
    Consensus CDS
    CCDS80439.1
    UniProtKB/Swiss-Prot
    Q99MR6
    Related
    ENSMUSP00000142564.2, ENSMUST00000197466.5
    Conserved Domains (2) summary
    pfam04959
    Location:645839
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)
  3. NM_001359602.1NP_001346531.1  serrate RNA effector molecule homolog isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC150682, AC243288
    Conserved Domains (2) summary
    pfam04959
    Location:645846
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)
  4. NM_031405.2NP_113582.1  serrate RNA effector molecule homolog isoform 1

    See identical proteins and their annotated locations for NP_113582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA986426, BC066831, CB195376, CJ175065
    Consensus CDS
    CCDS39331.1
    UniProtKB/Swiss-Prot
    Q3UD04, Q5D042, Q8VEE6, Q99MR4, Q99MR5, Q99MR6, Q99MR7
    Conserved Domains (2) summary
    pfam04959
    Location:645850
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137293966..137306564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254930.2XP_030110790.1  serrate RNA effector molecule homolog isoform X4

    Conserved Domains (2) summary
    pfam04959
    Location:418612
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:135
    DUF3546; Domain of unknown function (DUF3546)
  2. XM_030254929.2XP_030110789.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:418623
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:135
    DUF3546; Domain of unknown function (DUF3546)
  3. XM_006504631.3XP_006504694.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:480685
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:3297
    DUF3546; Domain of unknown function (DUF3546)
  4. XM_030254928.2XP_030110788.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:418623
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:135
    DUF3546; Domain of unknown function (DUF3546)
  5. XM_036165632.1XP_036021525.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:480685
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:3297
    DUF3546; Domain of unknown function (DUF3546)
  6. XM_036165633.1XP_036021526.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:418623
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:135
    DUF3546; Domain of unknown function (DUF3546)
  7. XM_030254927.2XP_030110787.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:480685
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:3297
    DUF3546; Domain of unknown function (DUF3546)
  8. XM_006504630.2XP_006504693.1  serrate RNA effector molecule homolog isoform X1

    See identical proteins and their annotated locations for XP_006504693.1

    Conserved Domains (2) summary
    pfam04959
    Location:548753
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:56165
    DUF3546; Domain of unknown function (DUF3546)