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SH3BGRL2 SH3 domain binding glutamate rich protein like 2 [ Homo sapiens (human) ]

Gene ID: 83699, updated on 24-Nov-2020


Official Symbol
SH3BGRL2provided by HGNC
Official Full Name
SH3 domain binding glutamate rich protein like 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000198478 MIM:615678
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Broad expression in salivary gland (RPKM 15.4), thyroid (RPKM 15.2) and 23 other tissues See more

Genomic context

See SH3BGRL2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (79631329..79703659)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (80341000..80413369)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506851 Neighboring gene lebercilin LCA5 Neighboring gene uncharacterized LOC112267857 Neighboring gene long intergenic non-protein coding RNA 1621 Neighboring gene cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Associated conditions

Description Tests
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
GeneReviews: Not available
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of SH3 domain binding glutamate-rich protein like 2 (SH3BGRL2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ90025

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
nuclear membrane IDA
Inferred from Direct Assay
more info
nucleoplasm IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
SH3 domain-binding glutamic acid-rich-like protein 2
SH3 domain binding glutamic acid-rich protein like 2
fovea-associated SH3 domain-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031469.4NP_113657.1  SH3 domain-binding glutamic acid-rich-like protein 2

    See identical proteins and their annotated locations for NP_113657.1

    Status: VALIDATED

    Source sequence(s)
    AF340151, AJ297972, DR422465
    Consensus CDS
    ENSP00000358853.4, ENST00000369838.6
    Conserved Domains (1) summary
    SH3BGR; SH3-binding, glutamic acid-rich protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536165.2XP_011534467.1  SH3 domain-binding glutamic acid-rich-like protein 2 isoform X1

    Conserved Domains (1) summary
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...
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