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SLC4A9 solute carrier family 4 member 9 [ Homo sapiens (human) ]

Gene ID: 83697, updated on 23-Nov-2021

Summary

Official Symbol
SLC4A9provided by HGNC
Official Full Name
solute carrier family 4 member 9provided by HGNC
Primary source
HGNC:HGNC:11035
See related
Ensembl:ENSG00000113073 MIM:610207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AE4
Summary
The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Biased expression in kidney (RPKM 5.2) and testis (RPKM 0.2) See more
Orthologs
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Genomic context

See SLC4A9 in Genome Data Viewer
Location:
5q31.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (140359645..140375177)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139739779..139754726)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 1 Neighboring gene heparin binding EGF like growth factor Neighboring gene ANKHD1-EIF4EBP3 readthrough Neighboring gene RNA, U4 small nuclear 14, pseudogene Neighboring gene ankyrin repeat and KH domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables anion:anion antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables inorganic anion exchanger activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:bicarbonate symporter activity TAS
Traceable Author Statement
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bicarbonate transport TAS
Traceable Author Statement
more info
 
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anion exchange protein 4
Names
anion exchanger 4
sodium bicarbonate cotransporter 5
solute carrier family 4, sodium bicarbonate cotransporter, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032676.1 RefSeqGene

    Range
    4993..19940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258426.2NP_001245355.1  anion exchange protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001245355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate in-frame splice junctions at three different exons compared to variant 1. The resulting isoform (3) lacks three alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC008438, AF332961, AF336237, CB046220
    Consensus CDS
    CCDS58975.1
    UniProtKB/Swiss-Prot
    Q96Q91
    Related
    ENSP00000410056.2, ENST00000432095.6
    Conserved Domains (3) summary
    TIGR00834
    Location:57900
    ae; anion exchange protein
    pfam00955
    Location:355853
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84306
    Band_3_cyto; Band 3 cytoplasmic domain
  2. NM_001258427.2NP_001245356.1  anion exchange protein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of another exon compared to variant 1. The resulting isoform (4) lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC008438, AF332961, BC136262, CB046220
    Consensus CDS
    CCDS58974.1
    UniProtKB/Swiss-Prot
    Q96Q91
    Related
    ENSP00000422855.1, ENST00000506545.5
    Conserved Domains (3) summary
    TIGR00834
    Location:57851
    ae; anion exchange protein
    pfam00955
    Location:355804
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84306
    Band_3_cyto; Band 3 cytoplasmic domain
  3. NM_001258428.2NP_001245357.1  anion exchange protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001245357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008438, AF313465, AF332961, CB046220
    Consensus CDS
    CCDS58973.1
    UniProtKB/Swiss-Prot
    Q96Q91
    Related
    ENSP00000427661.1, ENST00000507527.1
    Conserved Domains (3) summary
    TIGR00834
    Location:57938
    ae; anion exchange protein
    pfam00955
    Location:379891
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:108330
    Band_3_cyto; Band 3 cytoplasmic domain
  4. NM_031467.3NP_113655.2  anion exchange protein 4 isoform 2

    See identical proteins and their annotated locations for NP_113655.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AB032762, AC008438, AF332961, CB046220
    Consensus CDS
    CCDS47278.1
    UniProtKB/Swiss-Prot
    Q96Q91
    Related
    ENSP00000424424.1, ENST00000506757.7
    Conserved Domains (3) summary
    TIGR00834
    Location:57914
    ae; anion exchange protein
    pfam00955
    Location:355867
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84306
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    140359645..140375177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009933.1XP_016865422.1  anion exchange protein 4 isoform X1

  2. XM_017009940.1XP_016865429.1  anion exchange protein 4 isoform X10

  3. XM_017009934.1XP_016865423.1  anion exchange protein 4 isoform X2

  4. XM_017009938.1XP_016865427.1  anion exchange protein 4 isoform X8

  5. XM_017009941.1XP_016865430.1  anion exchange protein 4 isoform X11

  6. XM_017009935.1XP_016865424.1  anion exchange protein 4 isoform X3

  7. XM_017009942.1XP_016865431.1  anion exchange protein 4 isoform X12

  8. XM_017009937.1XP_016865426.1  anion exchange protein 4 isoform X6

  9. XM_017009936.1XP_016865425.1  anion exchange protein 4 isoform X5

  10. XM_005268521.3XP_005268578.2  anion exchange protein 4 isoform X7

    Conserved Domains (3) summary
    TIGR00834
    Location:81938
    ae; anion exchange protein
    pfam00955
    Location:379891
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:108330
    Band_3_cyto; Band 3 cytoplasmic domain
  11. XM_017009939.1XP_016865428.1  anion exchange protein 4 isoform X9

  12. XM_024446226.1XP_024301994.1  anion exchange protein 4 isoform X4

    Conserved Domains (1) summary
    cl26877
    Location:81962
    Band_3_cyto; Band 3 cytoplasmic domain
  13. XM_011537694.2XP_011535996.1  anion exchange protein 4 isoform X13

    Conserved Domains (2) summary
    pfam00955
    Location:403880
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:132354
    Band_3_cyto; Band 3 cytoplasmic domain
  14. XM_017009943.1XP_016865432.1  anion exchange protein 4 isoform X14

RNA

  1. XR_001742292.1 RNA Sequence

  2. XR_001742294.1 RNA Sequence

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