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RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 [ Homo sapiens (human) ]

Gene ID: 83695, updated on 5-Sep-2021

Summary

Official Symbol
RHNO1provided by HGNC
Official Full Name
RAD9-HUS1-RAD1 interacting nuclear orphan 1provided by HGNC
Primary source
HGNC:HGNC:28206
See related
Ensembl:ENSG00000171792 MIM:614085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RHINO; C12orf32; HKMT1188
Expression
Ubiquitous expression in thyroid (RPKM 7.6), lymph node (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See RHNO1 in Genome Data Viewer
Location:
12p13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (2876265..2889524)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2985431..2998690)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene testis expressed 52 Neighboring gene forkhead box M1 Neighboring gene TUB like protein 3 Neighboring gene RNA, U6 small nuclear 1315, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TULP3

Homology

Clone Names

  • FLJ60873, MGC13204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in recombinational repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in recombinational repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
Names
Rad9, Rad1, Hus1 interacting nuclear orphan
rAD9, RAD1, HUS1-interacting nuclear orphan protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252499.3NP_001239428.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 4 and 5 all encode isoform 1.
    Source sequence(s)
    AB073599, AI631627
    Consensus CDS
    CCDS8518.1
    UniProtKB/Swiss-Prot
    Q9BSD3
    Related
    ENSP00000438590.1, ENST00000489288.7
    Conserved Domains (1) summary
    pfam15319
    Location:1236
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein
  2. NM_001252500.3NP_001239429.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001239429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AB073599, AI631627, AK304613
    Consensus CDS
    CCDS58199.1
    UniProtKB/Swiss-Prot
    Q9BSD3
    Related
    ENSP00000438828.1, ENST00000461997.5
    Conserved Domains (1) summary
    pfam15319
    Location:1222
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein
  3. NM_001257097.2NP_001244026.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001244026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 all encode isoform 1.
    Source sequence(s)
    AB073599, AI631627, DA749974
    Consensus CDS
    CCDS8518.1
    UniProtKB/Swiss-Prot
    Q9BSD3
    Related
    ENSP00000479598.1, ENST00000618250.4
    Conserved Domains (1) summary
    pfam15319
    Location:1236
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein
  4. NM_001257098.2NP_001244027.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001244027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 all encode isoform 1.
    Source sequence(s)
    AB073599, AI631627, DA679606
    Consensus CDS
    CCDS8518.1
    UniProtKB/Swiss-Prot
    Q9BSD3
    Conserved Domains (1) summary
    pfam15319
    Location:1236
    RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

RNA

  1. NR_027365.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region, including the translational start codon, as found in variant 1.
    Source sequence(s)
    AI631627, AK021945
    Related
    ENST00000464682.2
  2. NR_046432.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB073599, AC005911, AI631627, DA378594
  3. NR_046433.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region, including the translational start codon, as found in variant 1.
    Source sequence(s)
    AI631627, AK021945, BM847461

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    2876265..2889524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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