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RPS6KL1 ribosomal protein S6 kinase like 1 [ Homo sapiens (human) ]

Gene ID: 83694, updated on 4-Dec-2022

Summary

Official Symbol
RPS6KL1provided by HGNC
Official Full Name
ribosomal protein S6 kinase like 1provided by HGNC
Primary source
HGNC:HGNC:20222
See related
Ensembl:ENSG00000198208 AllianceGenome:HGNC:20222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSKL2
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 4.6), testis (RPKM 3.0) and 22 other tissues See more
Orthologs
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Genomic context

See RPS6KL1 in Genome Data Viewer
Location:
14q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74903951..74923260, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69113051..69132361, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75370654..75389963, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 Neighboring gene METTL5 pseudogene 1 Neighboring gene HNF4 motif-containing MPRA enhancer 140 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene uncharacterized LOC107984690 Neighboring gene placental growth factor Neighboring gene eukaryotic translation initiation factor 2B subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35734, MGC11287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase-like 1
NP_001357181.1
NP_001357182.1
NP_001357184.1
NP_001357185.1
NP_001357186.1
NP_001357187.1
NP_113652.2
XP_011535508.1
XP_011535509.1
XP_011535513.1
XP_011535515.1
XP_016877169.1
XP_016877171.1
XP_016877172.1
XP_016877173.1
XP_016877174.1
XP_016877175.1
XP_016877177.1
XP_016877180.1
XP_024305484.1
XP_024305485.1
XP_047287752.1
XP_047287753.1
XP_047287754.1
XP_047287755.1
XP_047287756.1
XP_047287757.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034007.1 RefSeqGene

    Range
    4183..23492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370252.1NP_001357181.1  ribosomal protein S6 kinase-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148508
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  2. NM_001370253.1NP_001357182.1  ribosomal protein S6 kinase-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:146499
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  3. NM_001370255.1NP_001357184.1  ribosomal protein S6 kinase-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148305
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001370256.1NP_001357185.1  ribosomal protein S6 kinase-like 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148307
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001370257.1NP_001357186.1  ribosomal protein S6 kinase-like 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:131249
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001370258.1NP_001357187.1  ribosomal protein S6 kinase-like 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:131219
    PKc_like; Protein Kinases, catalytic domain
  7. NM_031464.5NP_113652.2  ribosomal protein S6 kinase-like 1 isoform 2

    See identical proteins and their annotated locations for NP_113652.2

    Status: VALIDATED

    Source sequence(s)
    AC006530, AK299846
    Consensus CDS
    CCDS9834.2
    UniProtKB/Swiss-Prot
    Q9BSU9, Q9Y6S9
    UniProtKB/TrEMBL
    B4DSP6
    Related
    ENSP00000450567.1, ENST00000557413.6
    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

RNA

  1. NR_163404.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006530
  2. NR_163405.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006530
  3. NR_163406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006530

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74903951..74923260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431797.1XP_047287753.1  ribosomal protein S6 kinase-like 1 isoform X6

  2. XM_017021682.2XP_016877171.1  ribosomal protein S6 kinase-like 1 isoform X2

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  3. XM_047431796.1XP_047287752.1  ribosomal protein S6 kinase-like 1 isoform X2

  4. XM_024449717.2XP_024305485.1  ribosomal protein S6 kinase-like 1 isoform X2

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  5. XM_011537206.4XP_011535508.1  ribosomal protein S6 kinase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011535508.1

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  6. XM_011537213.4XP_011535515.1  ribosomal protein S6 kinase-like 1 isoform X7

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:131492
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  7. XM_017021691.3XP_016877180.1  ribosomal protein S6 kinase-like 1 isoform X14

  8. XM_047431800.1XP_047287756.1  ribosomal protein S6 kinase-like 1 isoform X12

  9. XM_011537211.4XP_011535513.1  ribosomal protein S6 kinase-like 1 isoform X6

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:131508
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  10. XM_047431801.1XP_047287757.1  ribosomal protein S6 kinase-like 1 isoform X13

  11. XM_024449716.2XP_024305484.1  ribosomal protein S6 kinase-like 1 isoform X2

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  12. XM_017021688.3XP_016877177.1  ribosomal protein S6 kinase-like 1 isoform X11

    Conserved Domains (3) summary
    smart00220
    Location:177353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148353
    PKc_like; Protein Kinases, catalytic domain
  13. XM_017021683.3XP_016877172.1  ribosomal protein S6 kinase-like 1 isoform X3

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148525
    PKc_like; Protein Kinases, catalytic domain
  14. XM_017021684.3XP_016877173.1  ribosomal protein S6 kinase-like 1 isoform X4

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148523
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  15. XM_017021680.3XP_016877169.1  ribosomal protein S6 kinase-like 1 isoform X1

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  16. XM_011537207.3XP_011535509.1  ribosomal protein S6 kinase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011535509.1

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  17. XM_047431799.1XP_047287755.1  ribosomal protein S6 kinase-like 1 isoform X9

    Related
    ENSP00000450660.1, ENST00000555009.5
  18. XM_047431798.1XP_047287754.1  ribosomal protein S6 kinase-like 1 isoform X8

  19. XM_017021685.3XP_016877174.1  ribosomal protein S6 kinase-like 1 isoform X5

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
  20. XM_017021686.3XP_016877175.1  ribosomal protein S6 kinase-like 1 isoform X10

    Conserved Domains (2) summary
    cd02677
    Location:48122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148439
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    69113051..69132361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)