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CD99L2 CD99 molecule like 2 [ Homo sapiens (human) ]

Gene ID: 83692, updated on 21-Dec-2019

Summary

Official Symbol
CD99L2provided by HGNC
Official Full Name
CD99 molecule like 2provided by HGNC
Primary source
HGNC:HGNC:18237
See related
Ensembl:ENSG00000102181 MIM:300846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD99B; MIC2L1
Summary
This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in brain (RPKM 33.3), fat (RPKM 18.8) and 23 other tissues See more
Orthologs

Genomic context

See CD99L2 in Genome Data Viewer
Location:
Xq28
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (150766336..150898816, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (149934809..150067289, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene myotubularin 1 Neighboring gene myotubularin related protein 1 Neighboring gene cytochrome P450 family 2 subfamily C member 64, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 91 Neighboring gene RNA, U6 small nuclear 383, pseudogene Neighboring gene high mobility group box 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD99L2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761H2024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
diapedesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell extravasation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil extravasation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD99 antigen-like protein 2
Names
MIC2 like 1
MIC2-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021320.2 RefSeqGene

    Range
    5149..137481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184808.1NP_001171737.1  CD99 antigen-like protein 2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three consecutive in-frame exons in one region and an in-frame exon in another region, compared to variant 5. The resulting isoform (4) lacks two internal segments, compared to isoform 5.
    Source sequence(s)
    AF002223, AK293244, BC025729, DC323066
    Consensus CDS
    CCDS55527.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000394858.2, ENST00000437787.6
    Conserved Domains (1) summary
    pfam12301
    Location:30166
    CD99L2; CD99 antigen like protein 2
  2. NM_001242614.1NP_001229543.1  CD99 antigen-like protein 2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AK125020, AY358837, BC030536, DC323066
    Consensus CDS
    CCDS76044.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000480322.1, ENST00000613030.4
    Conserved Domains (1) summary
    pfam12301
    Location:30249
    CD99L2; CD99 antigen like protein 2
  3. NM_031462.4NP_113650.2  CD99 antigen-like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_113650.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the 3' region, compared to variant 5. The resulting isoform (1, also referred to as E3'-E4'-E3-E4) lacks an internal segment, compared to isoform 5.
    Source sequence(s)
    BC025729, BC030536
    Consensus CDS
    CCDS35427.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    UniProtKB/TrEMBL
    A0A024RC16
    Related
    ENSP00000359403.3, ENST00000370377.8
    Conserved Domains (1) summary
    pfam12301
    Location:30239
    CD99L2; CD99 antigen like protein 2
  4. NM_134445.4NP_604394.1  CD99 antigen-like protein 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_604394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three consecutive in-frame exons in one region and an in-frame exon in another region, compared to variant 5. The resulting isoform (3, also referred to as E4) lacks two internal segments, compared to isoform 5.
    Source sequence(s)
    AY078167, BC025729, DC323066
    Consensus CDS
    CCDS14697.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000347275.3, ENST00000355149.8
    Conserved Domains (1) summary
    pfam12301
    Location:30167
    CD99L2; CD99 antigen like protein 2
  5. NM_134446.4NP_604395.1  CD99 antigen-like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_604395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive in-frame exons in one region and an in-frame exon in another region, compared to variant 5. The resulting isoform (2, also referred to as E3-E4) lacks two internal segments, compared to isoform 5.
    Source sequence(s)
    AY078166, BC025729, DC323066
    Consensus CDS
    CCDS14698.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000417697.1, ENST00000466436.5
    Conserved Domains (1) summary
    pfam12301
    Location:30190
    CD99L2; CD99 antigen like protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    150766336..150898816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029891.2XP_016885380.1  CD99 antigen-like protein 2 isoform X2

  2. XM_017029890.2XP_016885379.1  CD99 antigen-like protein 2 isoform X1

  3. XM_011531202.2XP_011529504.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011529504.1

    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000489222.1, ENST00000346693.8
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