ABA1 zeaxanthin epoxidase (ZEP) (ABA1) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ABA1
Gene description: zeaxanthin epoxidase (ZEP) (ABA1)
Primary source: Araport:AT5G67030
Locus tag: AT5G67030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABA DEFICIENT 1; ARABIDOPSIS THALIANA ABA DEFICIENT 1; ARABIDOPSIS THALIANA ZEAXANTHIN EPOXIDASE; ATABA1; ATZEP; IBS3; IMPAIRED IN BABA-INDUCED STERILITY 3; K8A10.10; K8A10_10; LOS6; LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6; NON-PHOTOCHEMICAL QUENCHING 2; NPQ2; ZEAXANTHIN EPOXIDASE; ZEP
Summary: Encodes a single copy zeaxanthin epoxidase gene that functions in first step of the biosynthesis of the abiotic stress hormone abscisic acid (ABA). Mutants in this gene are unable to express female sterility in response to beta-aminobutyric acid, as wild type plants do.
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Genomic context

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See ABA1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 16

Sequence:: Chromosome: 5; NC_003076.8 (26753469..26757402, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZEP role in the carotenoid degradation in maturing seed.ZEP is expressed in the haplotype specific fashion during late seed development.
Title: ZEAXANTHIN EPOXIDASE Activity Potentiates Carotenoid Degradation in Maturing Seed.
aba1 may serve as an alternative model to other (1)singlet oxygen (O2-)overproducing mutants of Arabidopsis for investigating (1)O2-mediated cell death.
Title: Singlet oxygen triggers chloroplast rupture and cell death in the zeaxanthin epoxidase defective mutant aba1 of Arabidopsis thaliana under high light stress.
These data support a tissue- and stress-specific accumulation of the ZEP protein in accordance with its different functions in abscissic acid biosynthesis and the xanthophyll cycle.
Title: Tissue-specific accumulation and regulation of zeaxanthin epoxidase in Arabidopsis reflect the multiple functions of the enzyme in plastids.
ABA1 is required for skotomorphogenic growth, and beta-carotene-derived xanthophylls are putative regulators of skotomorphogenesis.
Title: The ABA1 gene and carotenoid biosynthesis are required for late skotomorphogenic growth in Arabidopsis thaliana.
AtZEP plays important roles in response to osmotic stress.
Title: Overexpression of Arabidopsis ZEP enhances tolerance to osmotic stress.
A description of the molecular and phenotypic characterization of a large series of mutant alleles of the ABA1 gene, which cause different degrees of ABA deficiency, four of them previously isolated and the remaining five novel, is presented.
Title: A mutational analysis of the ABA1 gene of Arabidopsis thaliana highlights the involvement of ABA in vegetative development.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_126103.2

Supported by ESTs:

NM_180954.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables zeaxanthin epoxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in abscisic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within abscisic acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to red light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sugar mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within xanthophyll biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: zeaxanthin epoxidase (ZEP) (ABA1)

NP_201504.2

ABA DEFICIENT 1 (ABA1); FUNCTIONS IN: zeaxanthin epoxidase activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zeaxanthin epoxidase (InterPro:IPR017079), Monooxygenase, FAD-binding (InterPro:IPR002938); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase family protein (TAIR:AT2G35660.1); Has 6741 Blast hits to 6737 proteins in 1083 species: Archae - 12; Bacteria - 3697; Metazoa - 0; Fungi - 1597; Plants - 576; Viruses - 0; Other Eukaryotes - 859 (source: NCBI BLink).

NP_851285.1

ABA DEFICIENT 1 (ABA1); FUNCTIONS IN: zeaxanthin epoxidase activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SMAD/FHA domain (InterPro:IPR008984), Zeaxanthin epoxidase (InterPro:IPR017079), Monooxygenase, FAD-binding (InterPro:IPR002938), Forkhead-associated (FHA) domain (InterPro:IPR000253); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase family protein (TAIR:AT2G35660.1); Has 6841 Blast hits to 6837 proteins in 1107 species: Archae - 14; Bacteria - 3761; Metazoa - 2; Fungi - 1599; Plants - 605; Viruses - 0; Other Eukaryotes - 860 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26753469..26757402 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180954.3 → NP_851285.1 zeaxanthin epoxidase (ZEP) (ABA1) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851285.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4K278, Q8RXE6, Q9FDX0, Q9FGC7, Q9FS21, Q9LDB9

UniProtKB/TrEMBL

A0A5S9YIH5, A0A654GET1

Conserved Domains (1) summary

PLN02927
Location:1 → 667

PLN02927; antheraxanthin epoxidase/zeaxanthin epoxidase
NM_126103.2 → NP_201504.2 zeaxanthin epoxidase (ZEP) (ABA1) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201504.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FGC7

UniProtKB/TrEMBL

A0A5S9YIH5, A0A654GET1

Conserved Domains (2) summary

PLN02927
Location:1 → 609

PLN02927; antheraxanthin epoxidase/zeaxanthin epoxidase

cl21454
Location:82 → 428

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins