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PAD2 proteasome alpha subunit D2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836746, updated on 15-Oct-2023

Summary

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Gene symbol
PAD2
Gene description
proteasome alpha subunit D2
Primary source
Araport:AT5G66140
Locus tag
AT5G66140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
20S PROTEASOME SUBUNIT PAD2; K2A18.22; K2A18_22; proteasome alpha subunit D2
Summary
Encodes alpha5 subunit of 20S proteosome complex involved in protein degradation.
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Genomic context

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Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (26437170..26438771, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene winged-helix DNA-binding transcription factor family protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene 3-dehydroquinate synthase Neighboring gene RADIATION SENSITIVE 17 Neighboring gene Glycosyl hydrolase family 38 protein Neighboring gene receptor homology region transmembrane domain ring H2 motif protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The glutathione-deficient mutant pad2-1 accumulates lower amounts of glucosinolates and is more susceptible to the insect herbivore Spodoptera littoralis. Schlaeppi K, et al. Plant J, 2008 Sep. PMID 18466300
  2. Identification of PAD2 as a gamma-glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis. Parisy V, et al. Plant J, 2007 Jan. PMID 17144898
  3. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
  4. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
  5. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAD2 encodes a gamma-glutamylcysteine synthetase involved in glutathione synthesis. pad2-1 mutants are glutathione-deficient and are more susceptible to Spodoptera littoralis because of a lower accumulation of glucosinolates.
    Title: The glutathione-deficient mutant pad2-1 accumulates lower amounts of glucosinolates and is more susceptible to the insect herbivore Spodoptera littoralis.
  2. The effect of PAD2 mutations on the susceptibility of A. thaliana to bacterial diseases is reported.
    Title: Identification of PAD2 as a gamma-glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_126012.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in plastid HDA PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex TAS
Traceable Author Statement
more info
 PubMed 
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
proteasome alpha subunit D2
NP_201415.1
  • proteasome alpha subunit D2 (PAD2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, proteasome core complex, alpha-subunit complex, chloroplast, vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome alpha subunit PAD1 (TAIR:AT3G51260.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    26437170..26438771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126012.4 → NP_201415.1  proteasome alpha subunit D2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201415.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24616, Q0WTK1, Q84W05
    UniProtKB/TrEMBL
    A0A178UMI1, A0A5S9YHF6
    Conserved Domains (2) summary
    PRK03996
    Location:1 → 229
    PRK03996; proteasome subunit alpha; Provisional
    cd03755
    Location:4 → 210
    proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O24616.2

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