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ACX2 acyl-CoA oxidase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836635, updated on 12-Aug-2026
Official Symbol
ACX2
Official Full Name
acyl-CoA oxidase 2
Primary source
TAIR:AT5G65110
Locus tag
AT5G65110
See related
Araport:AT5G65110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
acyl-CoA oxidase 2; ACYL-COA OXIDASE 2; ATACX2; MQN23.4; MQN23_4
Summary
Encodes an acyl-CoA oxidase presumably involved in long chain fatty acid biosynthesis.
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See ACX2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (26009521..26012684, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene K-box region/MADS-box transcription factor family protein Neighboring gene DNAse I-like superfamily protein Neighboring gene Ethylene insensitive 3 family protein Neighboring gene DNA-directed RNA polymerase subunit beta Neighboring gene Integrase-type DNA-binding superfamily protein

Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism. Pinfield-Wells H, et al. Plant J, 2005 Sep. PMID 16146525
  2. CATALASE2 functions for seedling postgerminative growth by scavenging H(2) O(2) and stimulating ACX2/3 activity in Arabidopsis. Liu WC, et al. Plant Cell Environ, 2017 Nov. PMID 28722222
  3. CATALASE2 Coordinates SA-Mediated Repression of Both Auxin Accumulation and JA Biosynthesis in Plant Defenses. Yuan HM, et al. Cell Host Microbe, 2017 Feb 8. PMID 28182949
  4. Long-chain acyl-CoA oxidases of Arabidopsis. Hooks MA, et al. Plant J, 1999 Oct. PMID 10571860
  5. Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions. Khan BR, et al. Plant Mol Biol, 2012 Jan. PMID 22048901

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAT2 functions in early seedling growth by scavenging hydrogen peroxide and stimulating ACX2/3 activity.
    Title: CATALASE2 functions for seedling postgerminative growth by scavenging H(2) O(2) and stimulating ACX2/3 activity in Arabidopsis.
  2. Data show that ACX5 levels were similar in the triple mutant and wild type, but ACX2 levels were increased in acx1acx3acx4 Columbia (Col) compared to wild-type.
    Title: Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions.
Submit: New GeneRIF Correction

Homology

NM_001037068.1
NM_125910.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyl-CoA oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Preferred Names
acyl-CoA oxidase 2
NP_001032145.1
  • acyl-CoA oxidase 2 (ACX2); CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA oxidase (InterPro:IPR012258), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA oxidase, C-terminal (InterPro:IPR002655), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 3 (TAIR:AT1G06290.1); Has 15850 Blast hits to 15835 proteins in 1495 species: Archae - 314; Bacteria - 10867; Metazoa - 1644; Fungi - 650; Plants - 316; Viruses - 0; Other Eukaryotes - 2059 (source: NCBI BLink).
NP_201316.1
  • acyl-CoA oxidase 2 (ACX2); CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA oxidase (InterPro:IPR012258), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA oxidase, C-terminal (InterPro:IPR002655), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 3 (TAIR:AT1G06290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    26009521..26012684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125910.6 → NP_201316.1  acyl-CoA oxidase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201316.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65201, Q9FJQ4
    UniProtKB/TrEMBL
    B9DG77
    Conserved Domains (1) summary
    PLN02636
    Location:4 → 692
    PLN02636; acyl-coenzyme A oxidase

  2. NM_001037068.1 → NP_001032145.1  acyl-CoA oxidase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001032145.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9DG77, F4KGI8
    Conserved Domains (2) summary
    cd01150
    Location:42 → 642
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02636
    Location:4 → 641
    PLN02636; acyl-coenzyme A oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O65201.2

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