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MS4A8 membrane spanning 4-domains A8 [ Homo sapiens (human) ]

Gene ID: 83661, updated on 1-Jun-2020

Summary

Official Symbol
MS4A8provided by HGNC
Official Full Name
membrane spanning 4-domains A8provided by HGNC
Primary source
HGNC:HGNC:13380
See related
Ensembl:ENSG00000166959 MIM:606549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MS4A4; 4SPAN4; CD20L5; MS4A8B
Summary
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 85.3), duodenum (RPKM 75.4) and 4 other tissues See more
Orthologs

Genomic context

See MS4A8 in Genome Data Viewer
Location:
11q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60699612..60715807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60467046..60483284)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A19, pseudogene Neighboring gene uncharacterized LOC105369321 Neighboring gene long intergenic non-protein coding RNA 301 Neighboring gene membrane spanning 4-domains A18 Neighboring gene membrane spanning 4-domains A15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membrane-spanning 4-domains subfamily A member 8
Names
four-span transmembrane protein 4
membrane-spanning 4-domains, subfamily A, member 8B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031457.2NP_113645.1  membrane-spanning 4-domains subfamily A member 8

    See identical proteins and their annotated locations for NP_113645.1

    Status: REVIEWED

    Source sequence(s)
    AF237905
    Consensus CDS
    CCDS7990.1
    UniProtKB/Swiss-Prot
    Q9BY19
    Related
    ENSP00000300226.2, ENST00000300226.7
    Conserved Domains (1) summary
    pfam04103
    Location:71207
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60699612..60715807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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