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TLN2 talin 2 [ Homo sapiens (human) ]

Gene ID: 83660, updated on 24-Nov-2021

Summary

Official Symbol
TLN2provided by HGNC
Official Full Name
talin 2provided by HGNC
Primary source
HGNC:HGNC:15447
See related
Ensembl:ENSG00000171914 MIM:607349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILWEQ
Summary
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues See more
Orthologs
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Genomic context

See TLN2 in Genome Data Viewer
Location:
15q22.2
Exon count:
59
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (62390550..62844631)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (62939510..63136830)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 6085 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 26 Neighboring gene Sharpr-MPRA regulatory region 10240 Neighboring gene uncharacterized LOC105370855 Neighboring gene uncharacterized protein MGC15885 Neighboring gene uncharacterized LOC105370854 Neighboring gene microRNA 190a Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene Neighboring gene TPM1 antisense RNA Neighboring gene tropomyosin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of sleep habits and insomnia.
GeneReviews: Not available
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0320, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
enables structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell junction assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 
located_in synapse NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033932.1 RefSeqGene

    Range
    5001..202321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394547.1NP_001381476.1  talin-2

    Status: REVIEWED

    Source sequence(s)
    AC011927, AC032011, AC068233, AC100839, AC103740
    Conserved Domains (9) summary
    cd12150
    Location:16561827
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:23372532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:312403
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:18501974
    VBS; Vinculin Binding Site
    cd17172
    Location:487
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:88199
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:209316
    FERM_M; FERM central domain
    pfam09141
    Location:494655
    Talin_middle; Talin, middle domain
    cl19756
    Location:689765
    I_LWEQ; I/LWEQ domain
  2. NM_015059.3NP_055874.2  talin-2

    See identical proteins and their annotated locations for NP_055874.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC011927, AC032011, AC068233, AC100839, AC103740
    Consensus CDS
    CCDS32261.1
    UniProtKB/Swiss-Prot
    Q9Y4G6
    Related
    ENSP00000453508.1, ENST00000561311.5
    Conserved Domains (9) summary
    cd12150
    Location:16561827
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:23372532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:312403
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:18501974
    VBS; Vinculin Binding Site
    cd17172
    Location:487
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:88199
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:209316
    FERM_M; FERM central domain
    pfam09141
    Location:494655
    Talin_middle; Talin, middle domain
    cl19756
    Location:689765
    I_LWEQ; I/LWEQ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    62390550..62844631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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