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FAM107B family with sequence similarity 107 member B [ Homo sapiens (human) ]

Gene ID: 83641, updated on 21-Mar-2023

Summary

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Official Symbol
FAM107Bprovided by HGNC
Official Full Name
family with sequence similarity 107 member Bprovided by HGNC
Primary source
HGNC:HGNC:23726
See related
Ensembl:ENSG00000065809 AllianceGenome:HGNC:23726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HITS; C10orf45
Summary
Predicted to act upstream of or within sensory perception of sound. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 45.0), kidney (RPKM 31.4) and 23 other tissues See more
Orthologs
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Genomic context

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See FAM107B in Genome Data Viewer
Location:
10p13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14518557..14774897, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14531882..14788860, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14560556..14816896, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902380 Neighboring gene MIR1265-FAM107B intergenic CAGE-defined T cell enhancer Neighboring gene uncharacterized LOC124902381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14600759-14601636 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:14690664-14691863 Neighboring gene uncharacterized LOC105376429 Neighboring gene RNA, 5S ribosomal pseudogene 302 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells. Guo J, et al. Cell Biol Int, 2017 Oct. PMID 28675500
  2. Loss of HITS (FAM107B) expression in cancers of multiple organs: tissue microarray analysis. Nakajima H, et al. Int J Oncol, 2012 Oct. PMID 22825356
  3. The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Patel YM, et al. Cancer Epidemiol Biomarkers Prev, 2015 Jan. PMID 25293881, Free PMC Article
  4. The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Whisenant TC, et al. PLoS One, 2015. PMID 26641092, Free PMC Article
  5. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054

See all (26) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors first provide experimental evidence suggesting that FAM107B was downregulated by S100A4 in gastric cancer MGC803 cells. And FAM107B at least partially mediates the biological effect of S100A4 in the cells.
    Title: FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.
  2. These results show that loss of HITS (FAM107B) expression is a common phenomenon observed in cancers of distinct organs and involved in tumor development and proliferation.
    Title: Loss of HITS (FAM107B) expression in cancers of multiple organs: tissue microarray analysis.
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45505, MGC11034, MGC90261

General protein information

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Preferred Names
protein FAM107B
Names
FAM107B/CDNF fusion
heat shock-inducible tumor small protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282695.2 → NP_001269624.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK127413, AL136885, BC144707
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  2. NM_001282696.2 → NP_001269625.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, BC072452
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000367728.4, ENST00000378467.8
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  3. NM_001282697.2 → NP_001269626.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, BC072452, DA543225
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000418120.1, ENST00000468747.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  4. NM_001282698.2 → NP_001269627.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK289959, AL136885
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000367719.2, ENST00000378458.6
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  5. NM_001282699.1 → NP_001269628.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK289959, AL136885, DA390740, DC327230
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000479842.1, ENST00000622567.4
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  6. NM_001282700.2 → NP_001269629.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, AL157706, DA813465, DA954468
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000419603.1, ENST00000479731.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  7. NM_001282701.2 → NP_001269630.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA409460
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000367726.3, ENST00000378465.7
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  8. NM_001282702.2 → NP_001269631.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA305421
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  9. NM_001282703.1 → NP_001269632.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK289959, AL136885, DA269906, DC327230
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000367723.1, ENST00000378462.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  10. NM_001320735.2 → NP_001307664.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, AL157706, DA954468, DB198416
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000420444.1, ENST00000468492.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  11. NM_001320736.2 → NP_001307665.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA962195, DC327230
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  12. NM_001320737.1 → NP_001307666.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA340804, DC332216
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  13. NM_001320738.2 → NP_001307667.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DB194372, DB240036
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  14. NM_001320739.2 → NP_001307668.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, BF979432
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000367731.1, ENST00000378470.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  15. NM_001320740.1 → NP_001307669.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA116139
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000420249.1, ENST00000489100.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  16. NM_001320741.2 → NP_001307670.1  protein FAM107B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and contains a novel 5' coding region compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL136885, AL157706, DA922675
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:47 → 159
    DUF1151; Protein of unknown function (DUF1151)

  17. NM_031453.4 → NP_113641.2  protein FAM107B isoform b

    See identical proteins and their annotated locations for NP_113641.2

    Status: VALIDATED

    Source sequence(s)
    AK127413, AL136885
    Consensus CDS
    CCDS7102.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000181796.2, ENST00000181796.7
    Conserved Domains (1) summary
    pfam06625
    Location:183 → 295
    DUF1151; Protein of unknown function (DUF1151)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    14518557..14774897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425814.1 → XP_047281770.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  2. XM_047425820.1 → XP_047281776.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  3. XM_047425823.1 → XP_047281779.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  4. XM_047425816.1 → XP_047281772.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  5. XM_047425821.1 → XP_047281777.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  6. XM_047425813.1 → XP_047281769.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  7. XM_047425819.1 → XP_047281775.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  8. XM_047425815.1 → XP_047281771.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  9. XM_047425822.1 → XP_047281778.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  10. XM_047425818.1 → XP_047281774.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  11. XM_047425817.1 → XP_047281773.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4

  12. XM_017016749.1 → XP_016872238.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000417782.1, ENST00000478076.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

  13. XM_005252616.5 → XP_005252673.1  protein FAM107B isoform X1

    See identical proteins and their annotated locations for XP_005252673.1

    UniProtKB/Swiss-Prot
    Q6ZSI4, Q9H098
    Related
    ENSP00000418330.1, ENST00000496330.5
    Conserved Domains (1) summary
    pfam06625
    Location:9 → 120
    DUF1151; Protein of unknown function (DUF1151)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    14531882..14788860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366883.1 → XP_054222858.1  protein FAM107B isoform X1

  2. XM_054366889.1 → XP_054222864.1  protein FAM107B isoform X1

  3. XM_054366893.1 → XP_054222868.1  protein FAM107B isoform X1

  4. XM_054366885.1 → XP_054222860.1  protein FAM107B isoform X1

  5. XM_054366890.1 → XP_054222865.1  protein FAM107B isoform X1

  6. XM_054366882.1 → XP_054222857.1  protein FAM107B isoform X1

  7. XM_054366888.1 → XP_054222863.1  protein FAM107B isoform X1

  8. XM_054366884.1 → XP_054222859.1  protein FAM107B isoform X1

  9. XM_054366891.1 → XP_054222866.1  protein FAM107B isoform X1

  10. XM_054366887.1 → XP_054222862.1  protein FAM107B isoform X1

  11. XM_054366886.1 → XP_054222861.1  protein FAM107B isoform X1

  12. XM_054366892.1 → XP_054222867.1  protein FAM107B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H098.1 GenPept UniProtKB/Swiss-Prot:Q9H098

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