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FAM107B family with sequence similarity 107 member B [ Homo sapiens (human) ]

Gene ID: 83641, updated on 24-Nov-2020

Summary

Official Symbol
FAM107Bprovided by HGNC
Official Full Name
family with sequence similarity 107 member Bprovided by HGNC
Primary source
HGNC:HGNC:23726
See related
Ensembl:ENSG00000065809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HITS; C10orf45
Expression
Ubiquitous expression in lymph node (RPKM 45.0), kidney (RPKM 31.4) and 23 other tissues See more
Orthologs

Genomic context

See FAM107B in Genome Data Viewer
Location:
10p13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (14518557..14774897, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14560556..14816896, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene microRNA 1265 Neighboring gene MIR1265-FAM107B intergenic CAGE-defined T cell enhancer Neighboring gene uncharacterized LOC105376429 Neighboring gene uncharacterized LOC105376428 Neighboring gene RNA, 5S ribosomal pseudogene 302 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene heat shock protein family A (Hsp70) member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45505, MGC11034, MGC90261

General protein information

Preferred Names
protein FAM107B
Names
FAM107B/CDNF fusion
heat shock-inducible tumor small protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282695.2NP_001269624.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK127413, AL136885, BC144707
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  2. NM_001282696.2NP_001269625.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, BC072452
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000367728.4, ENST00000378467.8
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  3. NM_001282697.2NP_001269626.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, BC072452, DA543225
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000418120.1, ENST00000468747.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  4. NM_001282698.2NP_001269627.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK289959, AL136885
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000367719.2, ENST00000378458.6
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  5. NM_001282699.1NP_001269628.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK289959, AL136885, DA390740, DC327230
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000479842.1, ENST00000622567.4
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  6. NM_001282700.2NP_001269629.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, AL157706, DA813465, DA954468
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000419603.1, ENST00000479731.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  7. NM_001282701.2NP_001269630.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA409460
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000367726.3, ENST00000378465.7
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  8. NM_001282702.2NP_001269631.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA305421
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  9. NM_001282703.1NP_001269632.1  protein FAM107B isoform a

    See identical proteins and their annotated locations for NP_001269632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
    Source sequence(s)
    AK289959, AL136885, DA269906, DC327230
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000367723.1, ENST00000378462.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  10. NM_001320735.2NP_001307664.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, AL157706, DA954468, DB198416
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000420444.1, ENST00000468492.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  11. NM_001320736.2NP_001307665.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA962195, DC327230
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  12. NM_001320737.1NP_001307666.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA340804, DC332216
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  13. NM_001320738.2NP_001307667.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DB194372, DB240036
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  14. NM_001320739.2NP_001307668.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, BF979432
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000367731.1, ENST00000378470.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  15. NM_001320740.1NP_001307669.1  protein FAM107B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
    Source sequence(s)
    AL136885, DA116139
    Consensus CDS
    CCDS60486.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000420249.1, ENST00000489100.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  16. NM_001320741.2NP_001307670.1  protein FAM107B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and contains a novel 5' coding region compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL136885, AL157706, DA922675
    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:47159
    DUF1151; Protein of unknown function (DUF1151)
  17. NM_031453.4NP_113641.2  protein FAM107B isoform b

    See identical proteins and their annotated locations for NP_113641.2

    Status: VALIDATED

    Source sequence(s)
    AK127413, AL136885
    Consensus CDS
    CCDS7102.1
    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000181796.2, ENST00000181796.6
    Conserved Domains (1) summary
    pfam06625
    Location:183295
    DUF1151; Protein of unknown function (DUF1151)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    14518557..14774897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519735.1XP_011518037.1  protein FAM107B isoform X1

    See identical proteins and their annotated locations for XP_011518037.1

    UniProtKB/Swiss-Prot
    Q9H098
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  2. XM_017016749.1XP_016872238.1  protein FAM107B isoform X1

    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000417782.1, ENST00000478076.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
  3. XM_005252616.4XP_005252673.1  protein FAM107B isoform X1

    See identical proteins and their annotated locations for XP_005252673.1

    UniProtKB/Swiss-Prot
    Q9H098
    Related
    ENSP00000418330.1, ENST00000496330.5
    Conserved Domains (1) summary
    pfam06625
    Location:9120
    DUF1151; Protein of unknown function (DUF1151)
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