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RAMAC RNA guanine-7 methyltransferase activating subunit [ Homo sapiens (human) ]

Gene ID: 83640, updated on 21-Dec-2019

Summary

Official Symbol
RAMACprovided by HGNC
Official Full Name
RNA guanine-7 methyltransferase activating subunitprovided by HGNC
Primary source
HGNC:HGNC:31022
See related
Ensembl:ENSG00000169612 MIM:614547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAM; RAMMET; C15orf18; FAM103A1; HsT19360
Expression
Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See RAMAC in Genome Data Viewer
Location:
15q25.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (82986210..82991057)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83654955..83659809)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene homer scaffold protein 2 Neighboring gene uncharacterized LOC105370928 Neighboring gene chromosome 15 open reading frame 40 Neighboring gene BTB domain containing 1 Neighboring gene fatty acid binding protein 5 pseudogene 8 Neighboring gene microRNA 4515

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2560, MGC102778

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to mRNA (guanine-N7-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping IDA
Inferred from Direct Assay
more info
PubMed 
RNA 5'-cap (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
 
methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
mRNA cap binding complex IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cap methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA guanine-N7 methyltransferase activating subunit
Names
RNMT activating mRNA cap methyltransferase subunit
RNMT-activating mini protein
family with sequence similarity 103 member A1
protein FAM103A1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031452.4NP_113640.1  RNA guanine-N7 methyltransferase activating subunit

    See identical proteins and their annotated locations for NP_113640.1

    Status: VALIDATED

    Source sequence(s)
    AC022558, BC112329, BQ002618
    Consensus CDS
    CCDS10321.1
    UniProtKB/Swiss-Prot
    Q9BTL3
    Related
    ENSP00000307181.3, ENST00000304191.4
    Conserved Domains (1) summary
    pfam15320
    Location:1087
    RAM; mRNA cap methylation, RNMT-activating mini protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    82986210..82991057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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