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H4C12 H4 clustered histone 12 [ Homo sapiens (human) ]

Gene ID: 8362, updated on 7-Jun-2020

Summary

Official Symbol
H4C12provided by HGNC
Official Full Name
H4 clustered histone 12provided by HGNC
Primary source
HGNC:HGNC:4784
See related
Ensembl:ENSG00000273542 MIM:602825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4/d; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FD; H4-16; H4C11; H4C13; H4C14; H4C15; H4F2iii; HIST1H4K; dJ160A22.1
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Genomic context

See H4C12 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27831174..27831560, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27798952..27799305, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 14 Neighboring gene H4 clustered histone 11 Neighboring gene H2A clustered histone 15 Neighboring gene H2B clustered histone 15

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
chromatin silencing at rDNA TAS
Traceable Author Statement
more info
 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
negative regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
telomere capping TAS
Traceable Author Statement
more info
 
telomere organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region HDA PubMed 
nuclear nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome TAS
Traceable Author Statement
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H4
Names
H4 histone family, member D
histone 1, H4k
histone cluster 1 H4 family member k
histone cluster 1, H4k

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003541.3NP_003532.1  histone H4

    See identical proteins and their annotated locations for NP_003532.1

    Status: REVIEWED

    Source sequence(s)
    AL049822
    Consensus CDS
    CCDS4631.1
    UniProtKB/Swiss-Prot
    P62805
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000479794.1, ENST00000611927.1
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27831174..27831560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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