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Nfe2l2 nuclear factor, erythroid 2-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83619, updated on 10-Oct-2019

Summary

Official Symbol
Nfe2l2provided by RGD
Official Full Name
nuclear factor, erythroid 2-like 2provided by RGD
Primary source
RGD:620360
See related
Ensembl:ENSRNOG00000001548
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
a basic leucine zipper transcription factor; involved in activating expression of genes with an antioxidant response element (ARE) [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 314.7), Adrenal (RPKM 305.6) and 9 other tissues See more
Orthologs

Genomic context

See Nfe2l2 in Genome Data Viewer
Location:
3q23
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (62497568..62525146, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (69041641..69069190, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554564 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene 60S ribosomal protein L10-like Neighboring gene uncharacterized LOC103691825

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Keap1-Nrf2, organism-specific biosystem (from WikiPathways)
    Keap1-Nrf2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
  • NFE2L2, organism-specific biosystem (from WikiPathways)
    NFE2L2, organism-specific biosystem
    NFE2L2
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Selenium metabolism Selenoproteins, organism-specific biosystem (from WikiPathways)
    Selenium metabolism Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription cofactor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
PubMed 
aflatoxin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
cell redox homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to fluid shear stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of hydrogen peroxide-induced cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide-induced cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
regulation of removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to copper ion IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter in response to copper ion ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromatin IEA
Inferred from Electronic Annotation
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex IEA
Inferred from Electronic Annotation
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
nuclear factor erythroid 2-related factor 2
Names
NF-E2-related factor 2
NFE2-related factor 2
nrf2
nuclear factor, erythroid derived 2, like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031789.2NP_113977.1  nuclear factor erythroid 2-related factor 2

    See identical proteins and their annotated locations for NP_113977.1

    Status: PROVISIONAL

    Source sequence(s)
    AF037350
    UniProtKB/Swiss-Prot
    O54968
    Related
    ENSRNOP00000002114.5, ENSRNOT00000002114.6
    Conserved Domains (1) summary
    cd14720
    Location:486553
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    62497568..62525146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234396.3XP_006234458.1  nuclear factor erythroid 2-related factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006234458.1

    UniProtKB/Swiss-Prot
    O54968
    Conserved Domains (1) summary
    cd14720
    Location:493560
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  2. XM_006234398.3XP_006234460.1  nuclear factor erythroid 2-related factor 2 isoform X2

    See identical proteins and their annotated locations for XP_006234460.1

    Conserved Domains (1) summary
    cd14720
    Location:477544
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
  3. XM_006234397.3XP_006234459.1  nuclear factor erythroid 2-related factor 2 isoform X2

    See identical proteins and their annotated locations for XP_006234459.1

    Conserved Domains (1) summary
    cd14720
    Location:477544
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    60095041..60122464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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