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Apba3 amyloid beta precursor protein binding family A member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83611, updated on 2-Oct-2018

Summary

Official Symbol
Apba3provided by RGD
Official Full Name
amyloid beta precursor protein binding family A member 3provided by RGD
Primary source
RGD:620846
See related
Ensembl:ENSRNOG00000020466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mint3
Summary
binds the cytoplasmic tail of amyloid beta precursor protein APP; also binds presenilin 1 cytoplasmic tail [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 117.7), Kidney (RPKM 112.8) and 9 other tissues See more
Orthologs

Genomic context

See Apba3 in Genome Data Viewer
Location:
7q11
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11314468..11319540, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (11481876..11486939, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene thromboxane A2 receptor Neighboring gene cactin, spliceosome C complex subunit Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene tight junction protein 3 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene megakaryocyte-associated tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
amyloid-beta A4 precursor protein-binding family A member 3; amyloid beta A4 precursor protein-binding family A member 3
Names
adapter protein X11gamma
amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)
amyloid beta (A4) precursor protein-binding, family A, member 3
mint-3
neuron-specific X11L2 protein
neuronal Munc18-1-interacting protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031781.1NP_113969.1  amyloid-beta A4 precursor protein-binding family A member 3

    See identical proteins and their annotated locations for NP_113969.1

    Status: PROVISIONAL

    Source sequence(s)
    AF029109
    UniProtKB/Swiss-Prot
    O70248
    Conserved Domains (2) summary
    cd00992
    Location:388473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    11314468..11319540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241018.2XP_006241080.1  amyloid beta A4 precursor protein-binding family A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006241080.1

    Conserved Domains (2) summary
    cd00992
    Location:388473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
  2. XM_006241020.2XP_006241082.1  amyloid beta A4 precursor protein-binding family A member 3 isoform X2

    See identical proteins and their annotated locations for XP_006241082.1

    UniProtKB/Swiss-Prot
    O70248
    Related
    ENSRNOP00000027784.2, ENSRNOT00000027784.4
    Conserved Domains (2) summary
    cd00992
    Location:388473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
  3. XM_006241019.2XP_006241081.1  amyloid beta A4 precursor protein-binding family A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006241081.1

    Conserved Domains (2) summary
    cd00992
    Location:388473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    6634549..6638968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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