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H4C4 H4 clustered histone 4 [ Homo sapiens (human) ]

Gene ID: 8360, updated on 23-Nov-2023


Official Symbol
H4C4provided by HGNC
Official Full Name
H4 clustered histone 4provided by HGNC
Primary source
See related
Ensembl:ENSG00000277157 MIM:602823; AllianceGenome:HGNC:4782
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4/b; H4C1; H4C2; H4C3; H4C5; H4C6; H4C8; H4C9; H4FB; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4D; dJ221C16.9
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
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Genomic context

See H4C4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26188710..26189112, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26057171..26057573, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26188938..26189340, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2BC6 antisense RNA 1 Neighboring gene H2B clustered histone 5 Neighboring gene LARP1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26172075-26172967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26183023-26183752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24198 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26187941-26188566 Neighboring gene H2B clustered histone 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26196641-26197242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26197243-26197843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24203 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26199013-26200212 Neighboring gene H1.12 linker histone, cluster member, pseudogene Neighboring gene H3 clustered histone 4 Neighboring gene H2A clustered histone 7

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
enables DNA binding TAS
Traceable Author Statement
more info
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
histone H4
H4 histone family, member B
histone 1, H4d
histone cluster 1 H4 family member d
histone cluster 1, H4d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003539.4NP_003530.1  histone H4

    See identical proteins and their annotated locations for NP_003530.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    ENSP00000479461.2, ENST00000614247.2
    Conserved Domains (1) summary
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    26188710..26189112 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    26057171..26057573 complement
    GenBank, FASTA, Sequence Viewer (Graphics)