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FOLK Phosphatidate cytidylyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835969, updated on 11-Jun-2025
Official Symbol
FOLK
Official Full Name
Phosphatidate cytidylyltransferase family protein
Primary source
TAIR:AT5G58560
Locus tag
AT5G58560
See related
Araport:AT5G58560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
farnesol kinase; MZN1.8; MZN1_8
Summary
FOLK is a farnesol kinase that can phosphorylate farnesol using an NTP donor. It can also phosphorylate geraniol, or geranylgeraniol, but it prefers farnesol in experiments performed using yeast membranes. folk loss-of-function mutants show ABA hypersensitivity in a seed germination assay and the mutants also exhibit abnormal flower development, including extra carpel formation, when subjected to water stress.
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See FOLK in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (23670267..23672877)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene ETO1-like 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene SAGA-associated factor-like protein

Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. Fitzpatrick AH, et al. Plant J, 2011 Jun. PMID 21395888
  2. Tocopherol and phylloquinone biosynthesis in chloroplasts requires the phytol kinase VITAMIN E PATHWAY GENE5 (VTE5) and the farnesol kinase (FOLK). Romer J, et al. Plant Cell, 2024 Mar 29. PMID 38124486, Free PMC Article
  3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Arabidopsis FOLK gene encodes a farnesol kinase capable of transferring the gamma-phosphate of ATP to farnesol.
    Title: Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description
NM_125242.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables prenol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prenol kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carpel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within farnesol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within isoprenoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vitamin E biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
Preferred Names
Phosphatidate cytidylyltransferase family protein
NP_200664.1
  • Phosphatidate cytidylyltransferase family protein; FUNCTIONS IN: phosphatidate cytidylyltransferase activity, transferase activity, transferring phosphorus-containing groups; INVOLVED IN: phospholipid biosynthetic process; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidate cytidylyltransferase (InterPro:IPR000374); BEST Arabidopsis thaliana protein match is: vitamin E pathway gene 5 (TAIR:AT5G04490.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    23670267..23672877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125242.4 → NP_200664.1  Phosphatidate cytidylyltransferase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200664.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q67ZA1, Q67ZM7, Q8LAW9, Q9LV00
    UniProtKB/TrEMBL
    A0A178U7L6, A0A5S9YF87, A0A654GC86
    Conserved Domains (1) summary
    cl21502
    Location:94 → 306
    CTP_transf_1; Cytidylyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q67ZM7.2

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