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THAP2 THAP domain containing 2 [ Homo sapiens (human) ]

Gene ID: 83591, updated on 17-Sep-2024

Summary

Official Symbol
THAP2provided by HGNC
Official Full Name
THAP domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20854
See related
Ensembl:ENSG00000173451 MIM:612531; AllianceGenome:HGNC:20854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 3.6), ovary (RPKM 2.6) and 24 other tissues See more
Orthologs
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Genomic context

See THAP2 in Genome Data Viewer
Location:
12q21.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (71664301..71680644)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (71641810..71658153)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (72058081..72074424)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902964 Neighboring gene MPRA-validated peak1819 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:71985323-71985838 Neighboring gene MPRA-validated peak1820 silencer Neighboring gene zinc finger C3H1-type containing Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6659 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:72057723-72058281 Neighboring gene uncharacterized LOC124902965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4658 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72080194-72080409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6662 Neighboring gene transmembrane protein 19 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72101517-72101722 Neighboring gene uncharacterized LOC107984530 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:72103459-72104658 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:72119048-72120247

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TMEM19

Clone Names

  • DKFZp564I0422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
THAP domain-containing protein 2
Names
THAP domain containing, apoptosis associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031435.4NP_113623.1  THAP domain-containing protein 2

    See identical proteins and their annotated locations for NP_113623.1

    Status: VALIDATED

    Source sequence(s)
    AC073612, AL136607, DB301707
    Consensus CDS
    CCDS9001.1
    UniProtKB/Swiss-Prot
    B2R8P3, Q9H0W7
    UniProtKB/TrEMBL
    Q6FIE1
    Related
    ENSP00000310796.2, ENST00000308086.3
    Conserved Domains (1) summary
    pfam05485
    Location:580
    THAP; THAP domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    71664301..71680644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    71641810..71658153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)