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H4C1 H4 clustered histone 1 [ Homo sapiens (human) ]

Gene ID: 8359, updated on 9-Jun-2024

Summary

Official Symbol
H4C1provided by HGNC
Official Full Name
H4 clustered histone 1provided by HGNC
Primary source
HGNC:HGNC:4781
See related
Ensembl:ENSG00000278637 MIM:602822; AllianceGenome:HGNC:4781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FA; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4A
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H4C1 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26021649..26022050)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25887588..25887989)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26021877..26022278)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H1.1 linker histone, cluster member Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26020191-26021007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26021008-26021824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26021825-26022640 Neighboring gene H3 clustered histone 1 Neighboring gene Sharpr-MPRA regulatory region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26027580-26028165 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26028166-26028750 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:26028751-26029336 Neighboring gene H4 clustered histone 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24180 Neighboring gene H3 clustered histone 2

Genomic regions, transcripts, and products

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, histone H4, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H4
Names
H4 histone family, member A
histone 1, H4a
histone cluster 1 H4 family member a
histone cluster 1, H4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003538.4NP_003529.1  histone H4

    See identical proteins and their annotated locations for NP_003529.1

    Status: REVIEWED

    Source sequence(s)
    U91328
    Consensus CDS
    CCDS4571.1
    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000479106.2, ENST00000617569.2
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    26021649..26022050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    25887588..25887989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)